倒班作业与高尿酸血症的剂量反应关系研究

Dose-response relationship between shift work and hyperuricemia

目的本研究旨在探讨钢铁工人加权倒班指数(weighted shift index,WSI)与高尿酸血症(hyperuricemia,HUA)之间的剂量反应关系。方法共有7 617例钢铁工人纳入本次研究。通过问卷调查和体格检查收集相关信息,应用限制性立方样条模型(restricted cubic spline,RCS)分析WSI与HUA之间的关系,并结合多因素Logistic回归模型分析其影响因素。结果研究人群中HUA的患病率为36. 2%(男性37. 5%,女性20. 9%),在调整了年龄、性别、吸烟、饮酒、饮食、体力活动、睡眠时间、睡眠质量、人均家庭月收入、受教育水平、健康状况之后,RCS模型分析结果显示钢铁工人WSI与HUA之间存在非线性的剂量反应关系(整体关联性检验X^2=30. 51,P <0. 001;非线性检验X^2=29. 71,P <0. 001)。结论 WSI与钢铁工人HUA之间存在非线性的剂量反应关系。

Objective To explore the dose-response relationship between weighted shift index （WSI） and hyperurieemia （HUA） in steel workers. Methods A total of 7 617 steel workers were interviewed with a standardized questionnaire and physically examined. We analyzed the cross-sectional relationship between WSI and HUA by restrictive cubic spline （RCS） model, and the potential confounders by muhi-faetor Logistic regression model. Results Among participants, 36. 2% of the individuals had hyperuricemia （37.5% in males and 20. 9% in females）. After adjusting for age, gender, smoking, drinking, diet, physical activity, sleep duration, sleep quality, monthly family income per capita, education, and health status, RCS model illustrated a nonlinear dose-response relationship between WSI and HUA in steel workers （X^2 = 30. 51, P 〈 0. 001 for overall association test and X^2 = 29. 71, P 〈 0. 001 for nonlinear test）. Conclusions There is a nonlinear dose-response relationship between WSI and HUA in steel workers.