PDOX联合细胞减灭术加腹腔热灌注化疗治疗VX-2胃癌并幽门梗阻的实验研究

Experimental study of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in the treatment of gastric carcinoma VX-2 and pyloric obstruction reduction combined with cell PDOX

目的研究PDOX联合细胞减灭术加腹腔热灌注化疗治疗VX-2胃癌并幽门梗阻的效果。方法选取40只健康大鼠作为研究对象,通过注射VX-2肿瘤细胞悬液建立鼠VX-2胃癌并幽门梗阻模型,将其以随机数字表法均分为研究组和对照组。对照组予以细胞减灭术加腹腔热灌注化疗治疗,研究组则在对照组的基础上予以PDOX治疗。分别比较两组大鼠各区域腹膜癌指数情况,腹水量、荷瘤质量以及生存期,脏器受累情况。结果研究组大鼠各区域腹膜癌指数明显低于对照组,差异均有统计学意义(P <0.05)。研究组大鼠腹水量与荷瘤质量分别为(8.21±2.75) mL、(14.52±4.49) g,明显低于对照组的(11.59±3.40) mL、(23.11±7.11) g,而研究组生存期为(54.23±18.05) d,明显高于对照组的(39.48±12.59) d,差异均有统计学意义(P <0.05)。研究组大鼠肺受累、盆腔受累以及肠壁受累占比分别为30.0%、25.0%、20.0%,均明显低于对照组的70.0%、60.0%、70.0%,差异均有统计学意义(P <0.05)。结论 PDOX联合细胞减灭术加腹腔热灌注化疗治疗VX-2胃癌并幽门梗阻具有显著的效果,可有效延长大鼠生存期,且有利于降低器官受累情况,安全性较好,值得临床推广应用。

Objective To study the effect of cytoreductive surgery combined with hyperthermicintraperitoneal chemotherapy in the treatment of gastric carcinoma VX- 2 and pyloric obstruction reductioncombined with cell PDOX. Methods 40 healthy rats were selected as the subjects. VX-2 gastric cancer wasestablished by injection of VX-2 tumor cell suspension and the model was divided into two groups studygroup and control group. The control group was treated by cytoreductive surgery plus intraperitonealhyperthermic perfusion chemotherapy. The study group was treated with PDOX on the basis of the control group.The peritoneal cancer index ascites volume tumor bearing quality survival time and organ involvement intwo groups were compared. Results The peritoneal cancer index in the study group was significantly lowerthan the control group differences between groups was statistically significant all P 〈 0. 05 . Quality ofwater and a tumor-burdened group rat′s abdomen respectively was 8.21 ± 2.75 mL 14.52 ± 4.49 g which were significantly lower than the control group of 11.59 ± 3.40 mL 23.11 ± 7. 11 g and thesurvival periods was 54.23 ± 18.05 d which was significantly higher than the control group of 39.48 ±12.59 d differences between groups was statistically significant all P 〈 0. 05 . Team in the rat lunginvolvement cardiac involvement pelvic involvement and intestinal wall involvement proportion were30.0% 25.0% 20.0% which were significantly lower than the control group of 70.0% 60.0% 70.0% differences between groups was statistically significant all P 〈 0.05 . Conclusion The treatment of VX-2gastric carcinoma with pyloric obstruction by the combination of cell reduction and intraperitonealhyperthermic chemotherapy is effective and can prolong the survival time of the rats. It is beneficial to reduceorgan involvement. It is safe and worthy of clinical application.