糖尿病肾脏疾病生物标志物的临床进展

Clinical progress of biomarkers for diabetic kidney disease

糖尿病已经成为我国慢性肾脏病的主要原因,然而对于诊断DKD有重要参考价值的生物标志物种类繁多,分类复杂。本文参考国内外文献,把DKD标志物分为肾小球损伤的生物标志物,肾小管损伤的生物标志物、炎症因子标志物、氧化应激标志物。各自阐述其文献出处、作者和首次发现时间,探讨生物学意义和局限性。尽管DKD标志物研究进展迅速,但尚未有一种生物标志物可单独作为DKD诊断的"金标准",而引用新技术分析蛋白组可能是未来的研究方向。

Diabetes has become the main cause of chronic kidney disease in China.However,there are many biomarkers that have diagnostic value for diabetic kidney disease.The classification of markers is complicated.In this review,diabetic kidney disease markers are classified into：However,there are many biomarkers that have diagnostic value for diabetic kidney disease.The classification of markers is complicated.In this review,diabetic kidney disease markers are classified into：biomarkers related to glomerular injury;biomarkers related to renal tubular injury;inflammatory factors;oxidative stress-related markers.At the same time,its literature,biological significance and limitations are introduced.Although research related to markers of diabetic kidney disease is progressing rapidly,there is no biomarker that can be used as a＂gold standard＂.Proteomics analysis using new technologies may be a potential tool.