辅酶Q_(10)在治疗高血压方面的应用进展

Advances in Application of Coenzyme Q_(10) in Treatment of Hypertension

高血压是心血管疾病最相关的独立危险因素之一,将血压降至正常水平能显著减少心血管事件发生。辅酶Q_(10)是人体自身合成的一种高效内源性脂溶性抗氧化物质,是细胞线粒体氧化呼吸链的固有成分,普通膳食补充并不足以满足病理状态下人体的需要。近年来的大量研究证实,外源性补充辅酶Q_(10)能有效降低高血压患者的收缩压及舒张压,且未发现其引起严重不良事件,其机制可能与减轻氧化应激与改善内皮功能等有关。作为一种安全的补充剂,辅酶Q_(10)在高血压治疗中的应用值得引起重视。

Hypertension is one of the most relevant independent risk factors for cardiovascular disease,and keeping blood pressure at a normal level can reduce cardiovascular events.Coenzyme Q 10 is a highly efficient endogenous fat-soluble antioxidant substance synthesized by the human body.It is an intrinsic component of the mitochondrial oxidative respiratory chain.The ordinary dietary supplement is not enough to meet the needs of the human body under pathological conditions.In recent years,a large number of studies have confirmed that exogenous coenzyme Q 10 can effectively reduce systolic blood pressure and diastolic blood pressure in patients with hypertension,and it has not been found to cause serious adverse events .The mechanism may be related to oxidative stress and endothelial function.As a safe supplement,coenzyme Q 10 is worth of due attention in the treatment of hypertension.