中性粒细胞与淋巴细胞比值与肿瘤预后的研究进展

Research Progress of Neutrophil to Lymphocyte Ratio in Tumor Prognosis

中性粒细胞与淋巴细胞比值(NLR)是近年来发现的全身炎症反应指标之一,反映了机体炎症反应及机体抗肿瘤免疫状态之间的平衡。研究发现,NLR在肿瘤的发生、发展中发挥重要作用。治疗前升高的NLR往往提示肿瘤患者在接受化疗、放疗、靶向治疗及免疫检查点抑制剂治疗后的低反应率,表明肿瘤患者的治疗效果不佳,而且高水平的NLR能有效预测行根治性切除术、移植术、微创等治疗患者的肿瘤复发风险增加、整体预后较差。NLR可以作为一项简单可靠的预后风险评估因素,指导肿瘤患者更好的治疗。

An indirect marker of a systemic inflammatory response is the neutrophil-to-lymphocyte ratio（NLR）,which can reflect the balance between inflammation and anti-tumor immunity in the body.NLR has been found to play an important role in the pathogenesis and progression of tumors.Evidence suggests that elevated NLR usually predicts lower response rate and poor treatment effects in the tumor patients treated with chemotherapy,radiotherapy,targeted therapy or immunologic checkpoint drug treatment.Moreover,higher NLR is correlated with higher recurrence rate and poor prognosis in many malignancies implemented radical resection,transplantation,and minimally invasive treatment.NLR is a more simple and reliable prognostic risk assessment factor,and can guide better treatment for the patients.