FeNO在儿童咳嗽变异性哮喘中的临床应用进展

Progress of Clinical Application of Fractional Exhaled Nitric Oxide for Cough Variant Asthma in Children

咳嗽变异性哮喘(CVA)在我国儿童慢性咳嗽病因中居首位,其病理改变与典型哮喘相似,且发展为典型哮喘的可能性大。CVA主要由气道炎症而发病,此种气道炎症与嗜酸粒细胞有密切关系。呼出气一氧化氮(FeNO)作为气道炎症的生物标志物,其检测气道炎症的功能在CVA的诊疗中具有广阔的应用前景。虽然FeNO在CVA患儿诊断、鉴别诊断及疗效评估等方面均具有一定的临床意义,但其正常浓度范围及在各个方面的参考值仍需进一步研究。

Cough variant asthma（CVA） is the leading cause of chronic cough in children in China.Its pathological changes are similar to typical asthma,and it is more likely to develop into typical asthma.CVA is mainly caused by airway inflammation,which is closely related to eosinophils.Fractional exhaled nitric oxide（FeNO）,as a biomarker of airway inflammation ,has a promising application in the diagnosis and treatment of CVA.Although FeNO has certain clinical significance in the diagnosis,differential diagnosis and evaluation of curative effect in children with CVA,its normal concentration range and reference value in various aspects still need further study.