Na^(+)-H^(+)交换阻滞剂与钙通道阻滞剂拮抗内皮素-1对离体血管的作用

Effects of Na^（＋）－H^（＋） Exchanging Blockers and Calcium Channel Blockers on Endothelin-1 in Isolated Aortic Ring of Rats

本实验采用Na＋－H＋交换阻滞剂呋喃苯氨酸（FUR）、布美他尼（BUM）和阿米洛利（AMI）及钙通过阻滞剂维拉帕米（VER）和盐酸川芎嗪（LIG），在离体血管上对内皮素－1（ET－1）缩血管效应的拮抗作用进行了初步研究。实验结果表明：1）Na＋－H＋交换阻滞剂与钙通道阻滞剂对于ET-1所引起的收缩血管的效应有明显的拮抗作用；2）舒张血管的效应呈现明显的剂量依赖性；3）Na＋－H＋交换阻滞剂的效能小于钙通道阻滞剂；4）经药效动力学分析，舒张血管的作用大小顺序为VER＞LIG＞AMI＞BUM＞FUR。提示Na＋－H＋交换阻滞剂与钙通道阻滞剂在离体动脉血管上可以拮抗ET－1收缩血管效应。

This study investigated the Na+-H+ exchanging blockers furosemide (FUR). bumetanide(BUM). amiloride and calcium channel blockers verapamil (VER). ligustrazine (LIG)antagonised the endothelin-1 (ET-1) contractile effects on isolated aortic ring of nomertensive rats. The results showed that;1) Na+-H+ exchanging blockers and calcium channel blockers could significantly inhibit the contractive effects of ET-1; 2) vasodilative effects were concentration dependence; 3) the potency of Na+-H+ exchanging blockers potency on vasodilation were smaller than calcium channel blockers; 4) with phamacodynamic analysis, the sequence of dilation were VER>LIG>AMI>BUM>FUR. This result suggested that Na+-H+ exchanging blockers and cailium channel blockers antagonisted ET-1 contractive effects on aortic rings of rats inhibit Ca2+ influx.