联合检测尿胰蛋白酶原-2和淀粉酶在诊断急性胰腺炎中的应用

Clinical value of combination of urine trypsinogen-2 and amylase test in the diagnosis of acute pancreatitis

目的探讨联合检测尿胰蛋白酶原-2和淀粉酶在急性胰腺炎中的应用效果。方法选择于我院门急诊就诊的上腹痛患者63例,同时进行血、尿淀粉酶和尿胰蛋白酶原-2检测。结果 36例急性胰腺炎患者中,尿胰蛋白酶原-2阳性34例,阳性率为94.4%,血淀粉酶阳性31例,阳性率为86.1%,尿淀粉酶阳性32例,阳性率为88.8%。胰蛋白酶原-2和淀粉酶两者阳性率有显著差异(P<0.05);27例非急性胰腺炎中,尿胰蛋白酶原-2阳性8例,特异性为70.4%,血淀粉酶阳性5例,特异性为81.5%,尿淀粉酶阳性7例,特异性为74.1%,两者特异性无显著差异(P>0.05)。结论联合检测尿胰蛋白酶原-2和血、尿淀粉酶可以提高急性胰腺炎筛选、诊断的准确率。

Objective To investigate the clinical value of combination of urine trysinogen-2 and serum amy-lase and urine amylase test in diagnosis of acute pancreatitis. Methods 63 patients admitting to the Outpatient and Emergency Department due to upper abdominal pain were included in the study. Serum amylase, urine amylase and urine trypsinogen-2 were assayed in all patients. Results 36 patients included in this study had acute pancreatitis diag-nosis. Urine trysinogen-2 was found positive in 34 （94.4%） patients. Serum urine amylase was found positive in 31 （86.1%） patients. Urine amylase was found positive in 32 （88.8%） patients. These values were signifcant difference （P〈0.05）. In 27 cases of non-acute pancreatitis, urine trysinogen-2 was positive in 8 patients. The specifcity was 70.4%. Serum amy-lase was positive in 5 patients. The specifcity was 81.5%. Urine amylase was positive in 7 patients. The specifcity was 74.1%. These values were no signifcant difference （P〉0.05）. Conclusion Combining urine trysinogen-2 and serum amy-lase and urine amylase test can improve the accuracy in screening and diagnosis of acute pancreatitis.