急性冠状动脉综合征患者血清膜突蛋白抗体含量测定及相关性分析

Detection and correlation analysis of serum moesin protein antibody in patients with acute coronary syndrome

目的探究膜突蛋白(Moesin)抗体在急性冠状动脉综合征(ACS)患者血清中的表达水平,及其与ACS病情严重程度的相关性。方法选取120例经冠状动脉造影确诊的ACS患者作为研究组,根据影像学显示的病变程度不同分为单支病变组(40例)、双支病变组(44例)、多支加左主干病变组(36例),并对所有患者进行全球急性冠状动脉事件注册(GRACE)评分;另选同期120例非ACS患者作为对照组。所有患者均用酶联免疫吸附试验(ELISA)试剂盒测定血清中Moesin抗体含量的OD值。结果对照组的总胆固醇(TC)、收缩压(SBP)、空腹血糖、ST段改变、心肌标志物改变情况均优于ACS组,差异具有统计学意义(P<0.05)。ACS组Moesin抗体检出率48.3%高于对照组的0.8%,差异具有统计学意义(P<0.05)。多支加左主干病变组Moesin抗体检出率及OD值分别为69.4%、(0.47±0.21),高于单支病变组的32.5%、(0.28±0.12),差异有统计学意义(P<0.05)。高危组患者血清Moesin抗体OD值(0.48±0.15)与低危组(0.26±0.16)、中危组(0.36±0.18)比较,中危组血清Moesin抗体OD值与低危组比较,差异均有统计学意义(P<0.05)。相关性分析显示Moesin抗体OD值与GRACE评分呈正相关(r=0.476, P<0.05)。结论 Moesin抗体是一种有价值的评价ACS病情的临床指标。

Objective To investigate the expression level of moesin protein antibody in serum of patients with acute coronary syndrome（ACS）, and its correlation with the severity of ACS. Methods A total of 120 patients with ACS confirmed by coronary angiography were taken as ACS group, and they were divided into singlevessel lesion group（40 cases）, double-vessel lesion group（44 cases）, multi-vessel and left main lesion group（36 cases） according to different of lesion shown by imaging. All patients were scored by global registry of acute coronary events（GRACE）. Another concurrent 120 non-ACS patients as control group. The OD value of Moesin antibody content in serum was determined by enzyme-linked immunosorbent assay（ELISA） kit in all patients. Results The control group had better total cholesterol（TC）, systolic blood pressure（SBP）, fasting blood glucose, ST segment and cardiac marker changes than ACS group, and their difference was statistically significant（P〈0.05）. ACS group had higher Moesin antibody detection rate as 48.3% than 0.8% in the control group, and the difference was statistically significant（P〈0.05）. Multi-vessel and left main coronary artery disease group had higher Moesin antibody detection rate and OD value respectively as 69.4% and（0.47±0.21） than 32.5% and（0.28±0.12） in single-vessel group, and the difference was statistically significant（P〈0.05）. The OD value of Moesin antibody in high-risk group was（0.48±0.15） which was significantly different from that of（0.26±0.16） in low-risk group and（0.36±0.18） in medium-risk group（P〈0.05）. Correlation analysis showed that the OD value of Moesin antibody was significantly correlated with GRACE score（r=0.476, P〈0.05）. Conclusion Moesin antibody is a valuable clinical indicator for evaluating the condition of ACS.