阿司匹林联合他汀类药物对老年脑血栓患者预后的影响观察

Effect observation on aspirin combined with statins on prognosis of senile patients with cerebral thrombosis

目的观察阿司匹林联合他汀类药物对老年脑血栓患者预后的影响。方法 86例老年脑血栓患者,随机分为观察组和对照组,各43例。对照组患者给予阿司匹林口服治疗,观察组在对照组基础上增加辛伐他汀口服治疗。对比两组患者治疗前后神经功能评分以及大脑中动脉平均血流量(MCV)、脑血管储备能力(CVR)、血流灌注指数(PI)。结果治疗前两组患者的神经功能评分比较差异无统计学意义(P>0.05);治疗后观察组患者神经功能评分(43.78±2.56)分,显著高于对照组的(34.21±2.13)分,差异具有统计学意义(P<0.05)。观察组患者MCV、CVR水平均显著高于对照组, PI值显著低于对照组,差异具有统计学意义(P<0.05)。结论老年脑血栓患者采用阿司匹林联合他汀类药物治疗,可显著改善患者脑部各项功能,药物联合服用较为安全,值得推广。

Objective To observe the effect of aspirin combined with statins on prognosis of senile patients with cerebral thrombosis. Methods A total of 86 senile patients with cerebral thrombosis were randomly divided into observation group and control group, with 43 cases in each group. The control group received oral aspirin for treatment, and the observation group received oral simvastatin on the basis of the control group. Comparison were made on neurological function score, mean corpuscular volume（MCV）, cerebrovascular reserve（CVR） and perfusion index（PI） were compared between the two groups before and after treatment. Results Before treatment, there was no statistically significant difference in neurological function score（P〈0.05）. After treatment, the observation group had significantly higher neurological function score as（43.78±2.56） points than（34.21±2.13） points in the control group, and the difference was statistically significant（P〈0.05）. The observation group had significantly higher MCV and CVR level than the control group, and significantly lower PI value than the control group. Their difference was statistically significant（P〈0.05）. Conclusion Application of aspirin and statins can significantly improve the brain function of senile patients with cerebral thrombosis, and the combination of drugs is safer. It is worthy of promotion.