靶向流感病毒进入(细胞)抑制剂研究进展

Recent progress of novel anti-influenza entry inhibitors

目前临床上抗流感病毒感染的药物主要有M2离子通道抑制剂及神经氨酸酶抑制剂两大类.随着流行性感冒、季节性流感、高致病性禽流感的爆发以及耐药流感病毒株的出现,使得对具有新作用机制的抗流感药物的需求更加紧迫.近年来,随着流感病毒进入细胞分子机制研究的深入,为以"病毒进入细胞为靶"的抗流感抑制剂的研究带来了契机.本文在介绍流感病毒进入细胞分子机制的基础上,重点介绍了靶向流感病毒进入的抑制剂及其作用机制的最新研究进展.

Currently, two classes of drugs used against influenza virus are M2 protein ion channel inhibitors and neuraminidase inhibitors. With the outbreaks of pandemic influenza, seasonal influenza and highly pathogenic avian influenza and the rapid emergence of drug-resistant influenza trains, it is urgent for the discovery of new anti-influenza drugs. Recently, the studies on molecular mechanism that influenza virus entries into cells bring opportunities for developing new anti-influenza entry inhibitors. In this paper, the anti-influenza entry inhibitors, their mechanism of action as well as the entry process of influenza virus were reviewed.