摘要
目前临床上抗流感病毒感染的药物主要有M2离子通道抑制剂及神经氨酸酶抑制剂两大类.随着流行性感冒、季节性流感、高致病性禽流感的爆发以及耐药流感病毒株的出现,使得对具有新作用机制的抗流感药物的需求更加紧迫.近年来,随着流感病毒进入细胞分子机制研究的深入,为以"病毒进入细胞为靶"的抗流感抑制剂的研究带来了契机.本文在介绍流感病毒进入细胞分子机制的基础上,重点介绍了靶向流感病毒进入的抑制剂及其作用机制的最新研究进展.
Currently, two classes of drugs used against influenza virus are M2 protein ion channel inhibitors and neuraminidase inhibitors. With the outbreaks of pandemic influenza, seasonal influenza and highly pathogenic avian influenza and the rapid emergence of drug-resistant influenza trains, it is urgent for the discovery of new anti-influenza drugs. Recently, the studies on molecular mechanism that influenza virus entries into cells bring opportunities for developing new anti-influenza entry inhibitors. In this paper, the anti-influenza entry inhibitors, their mechanism of action as well as the entry process of influenza virus were reviewed.
作者
李曼
李海伟
梁烁斌
田振宇
周德敏
肖苏龙
Man Li;Haiwei Li;Shuobin Liang;Zhenyu Tian;Demin Zhou;Sulong Xiao(State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)
出处
《中国科学:化学》
CAS
CSCD
北大核心
2018年第11期1347-1364,共18页
SCIENTIA SINICA Chimica
基金
国家自然科学基金(编号:91753202
81573269
21572015
21702007)
国家重点研发计划(编号:2016YFA0501500)资助项目
关键词
流感病毒
进入抑制剂
血凝素
膜融合
influenza virus
entry inhibitors
hemagglutinin
membrane fusion