药物涂层球囊在缺血性脑血管病介入治疗中的应用进展

Recent advance in drug eluting balloon in interventional treatment of ischemic cerebrovascular disease

目前，缺血性脑血管病的介入治疗发展迅速，但也面临着一些难题，如单纯球囊扩张术后再狭窄、支架内再狭窄、术后抗血小板治疗带来的出血风险等。药物涂层球囊（DEB）在冠状动脉疾病介入治疗中的良好效果为缺血性脑血管病的介入治疗提供了很好的借鉴。DEB作为一种新型技术，具有操作简单、术后双联抗血小板时间短、术后出血风险小、体内不留异物等优点。目前仅有的几个将DEB应用于缺血性脑血管病介入治疗的临床研究都取得了令人鼓舞的结果。本文现围绕DEB的作用机制、DEB在冠状动脉疾病介入治疗中的成熟经验及DEB在缺血性脑血管病介入治疗中的应用进展进行综述．以期为缺血性脑血管病的介入治疗提供新的思路。

The interventional treatment of ischemic cerebrovascular disease has developed rapidly, but it also faces some difficulties, such as restenosis after simple balloon dilatation, in-stent restenosis and bleeding risk caused by anti-platelet therapy after stent angioplasty. The good results and bright prospects of drug eluting balloon （DEB） in treatment of coronary intervention provide a nice reference for the treatment of cerebral vascular intervention. As a new technology, DEB has the advantages of easily operation, short time of postoperative dual anti-platelet treatment, low risk of postoperative bleeding and no foreign matter left in the body. At present, only a few studies have attempted to do the cerebral vascular interventional therapy with DEB, and the results are encouraging. In this paper, the mechanism, mature experience in coronary arteries and clinical application of DEB are summarized to provide a new idea for interventional treatment of ischemic cerebrovascular diseases.