维生素D代谢与风湿免疫性疾病的研究进展

Vitamin D metabolism and rheumatic autoimmune diseases

1，25（OH）2D是维生素D的活性形式，其对于钙磷代谢调节及骨骼健康均有重要作用。此外，1，25（OH）2D的另一个重要的非经典作用就是调节机体免疫，它可以增强固有免疫，还可通过调节获得性免疫降低自身免疫性疾病的发生。目前维生素D与风湿免疫性疾病中的类风湿性关节炎和系统性红斑狼疮相关性及1，25（OH）2D在这些疾病中的作用都有一定的了解，但对于如何补充维生素D辅助治疗这些疾病仍在探索阶段。现对维生素D代谢与风湿免疫性疾病的近期研究进展进行综述。

1,25 （OH）2 D, the active form of vitamin D, plays several roles in the body, influencing bone health as well as serum calcium and phosphate levels. Further, 1,25 （ OH ） 2 D plays an important role in modifying immune function including improving innate immunity and suppressing autoimmune diseases by regulating adaptive immunity. For now, there is already some understanding of the links between 1,25 （OH）2D and rheumatic autoimmune diseases like rheumatoid arthritis and system lupus erythematosus and its regulatory mechanisms involved in these diseases. However, supplement vitamin D in these patients is still in the exploratory stage. The purpose of this article is to summary the recent advances in the links between the metabolism of vitamin D and rheumatic autoimmune diseases.