Toll样受体4通过调节性T细胞引起不明原因复发性流产的机制研究进展

Role of Toll like receptor 4 in unexplained recurrent miscarriage induced by regulating T cells

母-胎界面免疫耐受状态异常是致不明原因复发性流产(URM)的重要原因之一,但其机制目前尚不明确。调节性T(regulatory T,Treg)细胞在维持母-胎界面免疫耐受中发挥重要作用。最新研究发现Toll样受体可能是调节Treg细胞增殖、分化和功能的关键。母-胎界面Toll样受体4(Toll like receptor 4,TLR4)参与调控Treg细胞抑制活性,参与诱导滋养细胞凋亡和影响Treg/Th17平衡,可影响免疫耐受状态致不明原因复发性流产(URM)发生。本文就蜕膜TLR4调节Treg细胞对URM发生的作用机制作一综述。

Abnormal state of the matemal-fetal interface tolerance is one of the important reasons of unexplained recurrent miscarriage （URM）, but its mechanism is not clear yet. Regulatory T （Treg） cells play an important role in the maintenance of maternal-fetal interface tolerance. The latest research has found that Toll like receptors may be the key to regulate proliferation, differentiation and function of Treg cells. The maternalfetal interface of Toll like receptor 4 （TLR4） participates in the regulation of Treg cell inhibitory activity and the induction of trophoblast apoptosis, influences the balance of Treg/Th 17, and may disturb the balance the immune tolerance and then cause URM. In this review, the of the URM decidua surface is reviewed. mechanism of TLR4 regulating Treg cells in the pathogenesis