内质网应激与肿瘤关系的研究进展

Research progress on the relationship between endoplasmic reticulum stress and tumors

内质网应激(endoplasmic reticulum stress, ERS)是细胞受到损伤因素(低氧、低PH、低营养等)作用时,Ca^(2+)平衡紊乱和蛋白质超负荷聚集在内质网所引发的反应。在应激条件下维持新生肽链正确折叠,是肿瘤细胞在低氧、酸中毒等应激环境中保持增殖和抗凋亡的关键因素。本文就内质网应激发生时细胞存活保护机制与肿瘤发生的关系进行综述。

Endoplasmic reticulum stress （ERS） is the response of cells to injury factors （hypoxia, low pH, low nutrients, etc.） leading to disorder of Ca2＋ balance and overload accumulation of protein in the endoplas- mic reticulum. Maintenance of nascent synthetic peptide folding correctly plays a key role in promoting tumor growth and anti-apoptosis in ERS, which induced by stress environment such as hypoxia, acidosis. Here we review the relationship between cell survive mechanisms in ERS and tumor development.