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乳腺浸润性导管癌实时剪切波弹性成像在病理分子分型中的应用价值 被引量:3

Application value of real-time shear wave elastography in distinguish of molecular subtypes in breast invasive ductal carcinoma
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摘要 目的探讨超声实时剪切波弹性成像与乳腺浸润性导管癌病理分子分型的关系。方法选取经手术或粗针穿刺病理证实的乳腺浸润性导管癌患者137例(共139个结节),均行超声实时剪切波弹性成像检查,并分析乳腺癌病理分子分型与剪切波弹性模量最大值(Emax)的相关性。结果乳腺浸润性导管癌的超声剪切波弹性模量Emax值由小到大依次为Luminal A型、Luminal B型、HER-2过表达型及三阴性型,其中Luminal A型和Luminal B型的超声剪切波弹性模量Emax值与三阴性型比较,差异有统计学意义(P<0.05)。Spearman相关分析显示,超声剪切波弹性模量Emax值与乳腺浸润性导管癌病理分子分型显著相关(r=0.510,P=0.003)。结论乳腺浸润性导管癌的超声剪切波弹性模量Emax值在鉴别其病理分子分型中有一定价值。 Objective To explore the relationship between the ultrasonic real-time shear wave elastography and molecular subtypes of breast invasive ductal carcinoma. Methods A total of 137 patients(139 nodules) with breast invasive ductal carcinoma were confirmed by operation or gross needle biopsy. Ultrasonic real-time shear wave elastography was performed,and the relationship between the maximum elastic modulus value and molecular subtypes were analyzed. Results The maximum value of shear wave elastic modulus in Luminal type A,Luminal type B,HER-2 overexpression type,triple negative type were getting larger. The maximum value of shear wave elastic modulus differed significantly between the triple negative type and the Luminal A,B types(P0.05).Spearman correlation analysis showed that the maximum value of ultrasonic real-time shear wave elastic modulus was significantly correlated with molecular subtypes(r=0.510,P=0.003). Conclusion The maximum value of ultrasonic real-time shear wave elastic modulus have a certain value in distinguish of molecular subtypes in breast invasive ductal carcinoma.
作者 王瑶琴 唐丽娜 刘娜香 陈轶洁 林若旋 钟兆明 Wang Yaoqin;Tang Lina;Liu Naxiang;Chen Yijie;Lin Ruoxuan;Zhong Zhaoming(Fujian Provincial Cancer Hospita;Department of Ultrasound,Affiliated Tumor Hospital of Fujian Medical University,Fuzhou 350014,China)
出处 《中国癌症防治杂志》 CAS 2018年第5期390-392,共3页 CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
基金 福建省卫生计生委青年科研资助项目(2015-2-6) 国家临床重点专科建设项目[(2013)544]
关键词 乳腺浸润性导管癌 实时剪切波弹性成像 弹性模量值 病理分子分型 Breast invasive ductal carcinoma Real-time shear wave elastography Elastic modulus value Pathological molecular typing
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  • 1Perou CM,Sorlie T,Eisen MB,et al.Molecular portraits of human breast tumours [ J ].Nature, 2000,406(6797 ):747-752.
  • 2Scrlie T,Perou CM,Tibshirani R,et al.Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical impli- cations[J].Proc Natl Acad Sci USA,2001,98(19):10869-10874.
  • 3Liu H,Fan Q,Zhang Z,et al.Basal-HER-2 phenotype shows poorer survival than basal-like phenotype in hormone receptor-negative in- vasive breast cancers[J].Hum Pathol,2008,39(2):167-174.
  • 4Cheang MC, Chia SK, Voduc D, et al.Ki-67 index, HER-2 status, and prognosis of patients with luminal B breast cancer[J].J Natl Can- cer Inst,2009,101(10):736-750.
  • 5Goldhirsch A,Wood WC ,Coates AS,et al.Strategies for subtypes- dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011 [J].Ann Oncol, 2011,22(8):1736-1747.
  • 6Goldhirsch A, Ingle JN, Gelber RD, et al.Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009 [J ].Ann Oncol, 2009,20 (8):1319-1329.
  • 7National Comprehensive Cancer Network. 2013 NCCN clinical prac- tice guidelines for breast cancer, Version 3 [ M/OL].http://www.nccn. org.2013.
  • 8Curigliano G,Criscitiello C,Andr F,et al.Highlights from the 13th St Gallen International Breast Cancer Conference 2013.Access to in- novation for patients with breast cancer:how to speed it np[J]?E- cancermedicalscience, 2013,7:299.
  • 9Giampaglia M, Chiuri VE, Tinelli A,et al.Lapatinib in breast can- cer:clinical experiences and future perspectives[J].Cancer Treat Rev,2010,36(Suppl 3):$72-79.
  • 10Capelan M, Pugliano L, De Azambuja E, et al.Pertuzumab:new hope for patients with HER-2-positive breast cancer[J].Ann Oncol,2013,24 (2) :273-282.

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