乳腺浸润性导管癌实时剪切波弹性成像在病理分子分型中的应用价值

Application value of real-time shear wave elastography in distinguish of molecular subtypes in breast invasive ductal carcinoma

目的探讨超声实时剪切波弹性成像与乳腺浸润性导管癌病理分子分型的关系。方法选取经手术或粗针穿刺病理证实的乳腺浸润性导管癌患者137例(共139个结节),均行超声实时剪切波弹性成像检查,并分析乳腺癌病理分子分型与剪切波弹性模量最大值(Emax)的相关性。结果乳腺浸润性导管癌的超声剪切波弹性模量Emax值由小到大依次为Luminal A型、Luminal B型、HER-2过表达型及三阴性型,其中Luminal A型和Luminal B型的超声剪切波弹性模量Emax值与三阴性型比较,差异有统计学意义(P<0.05)。Spearman相关分析显示,超声剪切波弹性模量Emax值与乳腺浸润性导管癌病理分子分型显著相关(r=0.510,P=0.003)。结论乳腺浸润性导管癌的超声剪切波弹性模量Emax值在鉴别其病理分子分型中有一定价值。

Objective To explore the relationship between the ultrasonic real-time shear wave elastography and molecular subtypes of breast invasive ductal carcinoma. Methods A total of 137 patients（139 nodules） with breast invasive ductal carcinoma were confirmed by operation or gross needle biopsy. Ultrasonic real-time shear wave elastography was performed,and the relationship between the maximum elastic modulus value and molecular subtypes were analyzed. Results The maximum value of shear wave elastic modulus in Luminal type A,Luminal type B,HER-2 overexpression type,triple negative type were getting larger. The maximum value of shear wave elastic modulus differed significantly between the triple negative type and the Luminal A,B types（P0.05）.Spearman correlation analysis showed that the maximum value of ultrasonic real-time shear wave elastic modulus was significantly correlated with molecular subtypes（r=0.510,P=0.003）. Conclusion The maximum value of ultrasonic real-time shear wave elastic modulus have a certain value in distinguish of molecular subtypes in breast invasive ductal carcinoma.