非酒精性脂肪肝患者颈桡脉搏波传导速度的变化和相关因素的研究

Research about Non-alcoholic Fatty Liver Disease Patients' Carotid Radial Pulse Wave Velocity's Patterns and Associated Factors

目的:探讨非酒精脂肪性肝病(NAFLD)患者的颈桡动脉脉搏波传导速度(crPWV)的变化和相关因素的分析。方法:收集患者的一般资料和血液生化指标、肝脏超声及中心动脉压、crPWV的检测结果,依据肝脏超声报告分为NAFLD组及非NAFLD组,通过方差分析和卡方检验对比两组的资料的差别,通过多元线性逐步回归探讨影响crPWV的相关因素。结果:非NAFLD组比较,NAFLD组男性、糖尿患者数多,内脏脂肪率、甘油三酯、VLDL、ALT、ALT/AST、GGT、胆碱酯酶、尿酸、cDBP和crPWV显著增高,差异均有统计学意义(P<0.05)。男性、cDBP和甘油三酯进入NAFLD患者的crPWV多元线性逐步回归方程,β值分别为0.779、0.050和-0.167,P<0.05。结论:NAFLD患者crPWV显著升高,cDBP是NAFLD患者crPWV增高的独立危险因素。

Objective：Analyse non-alcoholic fatty liver disease（NAFLD） patients＇ carotid radial pulse wave velocity（crPWV）＇s patterns and associated factors.Method：General data and blood biochemical indexes,liver ultrasound,central arterial pressure and crPWV were collected.According to liver ultrasound report, all patients were divided into NAFLD group and non-NAFLD group.The data of the two groups were compared by variance analysis and chi-square test,and the related factors affecting crPWV were studied by multivariate linear stepwise regression.Result：Compared with non-NAFLD group,NAFLD group had more male and diabetes patients,level of visceral fat rate,triglyceride, VLDL,ALT,ALT/AST,GGT, cholinesterase, uric acid,cDBP and crPWV were significantly higher.In NAFLD patients,male,NAFLD and cDBP were factors in the multi-linear stepwise regression model,with βwere 0.779,0.050 and-0.167.Conclusion：NAFLD patients＇ crPWV was significantly higher,cDBP was an independent risk factor for crPWV in NAFLD patients.