研究集束化治疗对综合ICU严重脓毒症患者预后的影响

Study on the effect of cluster therapy on the prognosis of severe sepsis patients with ICU

目的探讨综合ICU严重脓毒症患者采用集束化治疗的预后效果。方法选取2016年1月～2017年12月期间本院收入ICU治疗的严重脓毒症患者共计30例作为研究对象,将其分为观察组与对照组,各15例,其中观察组患者采用集束化治疗方法,对照组患者采用常规方法治疗,对比两组患者临床效果。结果观察组患者治疗7 d后其序贯器官衰竭估计评分(SOFA)评分显著优于对照组(P<0.05);观察组患者ICU停留时间显著短于对照组(P<0.05);观察组患者血管活性药物使用时间显著短于对照组(P<0.05);观察组患者28 d机械通气时间显著短于对照组(P<0.05);观察组患者其4周病死率显著低于对照组(P<0.05)。结论 ICU严重脓毒症患者经集束化治疗后其病死率显著下降,患者SOFA评分改善显著,同时通过集束化治疗的开展还能够减少患者血管活性药物的使用时间和机械通气时间,缩短ICU停留时间,具有推广应用效果。

Objective To investigate the prognosis of patients with severe sepsis combined with ICU. Methods From January 2016 to December 2017, 30 patients with severe sepsis received ICU treatment in our hospital were selected and divided into observation group and control group, 15 cases in each group. Patients in observation group were treated with cluster therapy, while patients in control group were treated with routine therapy. The clinical effects of the two groups were compared. Results Sequential organ failure assessment score （SOFA） of the observation group was significantly better than that of the control group 7 days after treatment, stay time was significantly shorter than that of the control group （P〈0.05）, and the 4 weeks mortality of the observation group was significantly lower than that of the control group （P〈0.05）. Conclusion The mortality of patients with severe sepsis in ICU decreased significantly after cluster therapy, and the SOFA score of patients improved significantly. At the same time, the use of vasoactive drugs and mechanical ventilation time could be reduced and the residence time of ICU could be shortened by cluster therapy.