放化疗同步治疗对食道癌术后的临床疗效及对复发的影响

Effect of radiotherapy and chemotherapy on the clinical effect of esophagus cancer and its effect on recurrence

目的探讨放化疗同步治疗对食道癌术后的临床疗效及对近期复发、生存情况的影响。方法选取本院2015年10月～2016年10月期间收治的76例食道癌术后接受放化疗的患者为研究对象,随机将其分为对照组与观察组,各38例。对照组患者采用单纯TP化疗方案治疗,观察组患者采用TP化疗方案+三维适形调强放疗同步治疗,比较两组患者临床疗效、近期复发及生存率情况。结果观察组中完全缓解6例、部分缓解25例,总有效率81.58%,对照组完全缓解4例、部分缓解18例,总有效率57.89%,观察组总有效率明显高于对照组(P<0.05);两组患者6个月、12个月复发率及生存率比较差异无统计学意义;观察组24个月复发率明显低于对照组,24个月生存率明显高于对照组(P<0.05)。结论放化疗同步治疗可有效提高食道癌患者术后的临床疗效及生存率,降低近期复发率,临床疗效显著,值得推广应用。

Objective To investigate the effect of radiotherapy and chemotherapy on the clinical efficacy of esophagus cancer and its effect on the recent recurrence and survival. Methods A total of 76 patients who received radiotherapy and chemotherapy after esophagus cancer surgery in October 2015 to October 2016 were selected and randomly divided into control group and observation group, 38 cases in each group. The control group was treated with TP chemotherapy alone, while the observation group received TP chemotherapy plus three dimensional conformal intensity modulated radiation therapy. The clinical efficacy, short-term recurrence and survival rate of the two groups were compared. Results In the observation group, 6 cases of complete remission, partial remission in 25 cases, the total efficiency of 81.58%, control group 4 cases of complete remission, partial remission in 18 cases, the total efficiency of 57.89%, the total efficiency of the observation group was significantly higher than the control group （P〈0.05）; there is no significant difference between the two groups in 6 months and 12 months recurrence rate and survival rate; the recurrence rate of the observation group during 24 months was significantly lower than the control group and the survival rate was significantly higher than that of the control group （P〈 0.05）. Conclusion Concurrent chemoradiotherapy can effectively improve the clinical efficacy and survival rate of esophageal cancer patients, reduce the short-term recurrence rate, and has significant clinical effect, which is worthy of popularization and application.