神经节苷脂对脑性瘫痪患儿神经功能及免疫炎性因子水平的影响

Effects of gangliosides on neurological function and levels of immune inflammatory factors in children with cerebral palsy

目的研究神经节苷脂对脑性瘫痪(CP)患儿神经功能及免疫炎性因子水平的影响。方法选择我院2017年1月至2017年12月收治的96例CP患儿,将其按随机数字表法分为研究组与对照组,各48例。对照组给予常规康复锻炼,研究组在对照组基础上给予神经节苷脂治疗。6个疗程后,比较两组患儿综合功能、血清免疫炎性因子水平及药物不良反应发生情况。结果治疗后,两组患儿的认知、语言、运动、社会适应性、自理动作评分及总分均显著高于治疗前,且研究组均高于对照组(P<0.05);治疗后,两组患儿血清IL-6、TNF-α水平均显著降低,且研究组低于对照组(P<0.05)。且治疗期间两组患儿均未出现皮疹、过敏等药物不良反应。结论神经节苷脂可促进CP患儿康复,能改善患儿认知、语言等功能,降低血清免疫炎性因子水平,安全性好。

Objective To study the effects of gangliosides on neurological function and levels of immune inflammatoryfactors in children with cerebral palsy （CP）. Methods A total of 96 children with CP in our hospital from January 2017 toDecember 2017 were selected and divided into study group and control group according to the random number tablemethod, with 48 cases in each group. The control group was given routine rehabilitation exercise, and the study group wasgiven gangliosides on the basis of the control group. After 6 courses of treatment, the comprehensive function, levels ofserum immune inflammatory factors and adverse drug reactions were compared between the two groups. Results Aftertreatment, the scores of cognition, language, exercise, social adaptability, self-care behavior and the total scores in the twogroups increased, and those in the study group were higher than the control group （P〈0.05）. After treatment, the levels ofserum IL-6 and TNF-α in the two groups decreased, and those in the study group were lower than the control group（P〈0.05）.During treatment, there was no adverse drug reactions such as rash or allergy occurred in the two groups. ConclusionGangliosides in children with CP can promote the rehabilitation, improve the cognitive, language and other functions, anddecrease the levels of serum immune inflammatory factors, and with good safety.