摘要
目的研究消瘤保肺丸联合冷冻消融及化疗治疗晚期非小细胞肺癌的临床效果,观察消瘤保肺丸对临床疗效的影响。方法选择2014年5月至2016年4月该院住院治疗的134例非小细胞肺癌患者为研究对象,随机分为两组,每组67例。对照组采用冷冻消融联合化疗进行治疗,观察组在对照组治疗方案的基础上,加用消瘤保肺丸。记录并比较两组患者实体瘤的临床治疗效果,两组患者治疗前后免疫功能的改善情况和生活质量改善情况,比较两组患者主要不良反应的发生率。结果在实体瘤临床疗效比较中,观察组患者的临床控制率为68.7%,明显高于对照组的50.7%,差异有统计学意义(P<0.05);在患者免疫功能改善比较中,与治疗前比较,两组患者治疗后的CD4^+和CD4^+/CD8^+均明显升高,CD8^+均明显下降,且观察组变化幅度更为明显,高于对照组,差异有统计学意义(P<0.05);在两组患者生活质量改善情况比较中,观察组患者总改善率可达73.1%,明显高于对照组的58.2%,两组间比较差异有统计学意义(P<0.05);两组患者不良反应均以肝肾损伤、骨髓抑制、脱发、白细胞降低为主,其中观察组上述不良反应的发生率明显低于对照组,差异有统计学意义(P<0.05)。结论消瘤保肺丸联合冷冻消融、化疗治疗晚期非小细胞肺癌临床效果显著,可明显的控制肿瘤生长,提高患者的免疫力,降低不良反应发生率,并最终提高患者的生活质量,值得在临床使用中推广。
Objective To study the clinical effect of Xiaoliu Baofei pill combined with cryoablation and chemotherapy in the treatment of advanced non-small cell lung cancer. Methods From April 2014 to April 2016,134 patients with non-small cell lung cancer were enrolled in our hospital.They were randomly divided into two groups:67 cases in each group.The control group was treated with cryoablation combined with chemotherapy.The observation group was treated with anti-tumor Xiaoliu Baofei pills in addtion.The clinical treatment of solid tumors was recorded and compared.The improvement of immune function and the improvement of quality of life were analyzed before and after treatment.Finally,the incidence of major adverse reactions were compared between the two groups. Results The effective rate was 68.7% in the observation group,which was significantly higher than that in the control group(50.7%),and the difference was statistically significant( P 〈0.05).In the comparison of the immune function of the patients,the levels of CD4 + and CD4 +/CD8 + were both increased in both groups after treatment,CD8 + were significantly decreased.And the change of observation group was significantly higher than that of control group( P 〈0.05).The improvement rate of the patients in the observation group was 73.1%,which was significantly higher than that in the control group(58.2%).There was significant difference between the two groups( P 〈0.05).Liver and kidney injury,bone marrow depression,alopecia and leukocytopenia were the main adverse reactions.The incidence of adverse reactions was significantly lower in the observation group than in the control group( P 〈0.05). Conclusion Xiaoliu Baofei pill combined with cryoablation and chemotherapy in the treatment of advanced non-small cell lung cancer has obvious clinical effect,which could control tumor growth,improve the immunity of patients,reduce the incidence of adverse reactions,and ultimately improve the quality of life of patients.It is worthy for clinical use.
作者
丁富强
王可为
高海妮
张静
DING Fuqiang;WANG Kewei;GAO Haini;ZHANG Jing(Department of Oncology,Baoji Hospital Affiliated of Xi′an MedicalCollege,Baoji,Shaanxi 721006,China)
出处
《检验医学与临床》
CAS
2018年第23期3573-3575,3578,共4页
Laboratory Medicine and Clinic
关键词
消瘤保肺丸
冷冻消融
非小细胞肺癌
疗效
Xiaoliu Baofei pill
cryoablation
non-small cell lung cancer
efficacy