首发型未服药非器质性睡眠障碍患者前瞻性记忆与工作记忆相关分析

Analysis of correlation between prospective memory and working memory in first-episode treatment-naive patients with nonorganic insomnia

目的探讨首发型未服药非器质性睡眠障碍(NI)患者前瞻性记忆与工作记忆之间的相关性。方法将2015年1月至2016年1月在安徽省精神卫生中心首次就诊未服药的80例NI患者设为观察组(NI组),同时期选择与其人口学资料相匹配的80例合肥社区志愿者作为健康对照组(HC组),采用基于事件前瞻性记忆(EBPM)范式和基于时间前瞻性记忆(TBPM)范式评估两组患者EBPM、TBPM得分,通过客体、语音及空间工作记忆测试评估两组患者的反应时间及错误数,比较两组研究对象EBPM、TBPM得分及客体、语音及空间工作记忆反应时长及错误数。采用Pearson相关分析NI组前瞻性记忆与工作记忆相关性。结果NI组在EBPM和TBPM得分低于HC组,差异有统计学意义[(3. 53±0. 75)分比(3. 95±0. 90)分;(3. 15±1. 16)分比(3. 75±1. 07)分,P均<0. 05],NI组在工作记忆中客体和空间工作记忆的反应时长均长于HC组,差异均有统计学意义[(1 448. 95±294. 54) ms比(1 310. 20±180. 30) ms;(1 485. 26±271. 59) ms比(1 397. 68±268. 08) ms,P均<0. 05]; Pearson相关分析显示,NI组EMPI得分与客体工作记忆反应呈负相关(r=-0. 310,P=0. 005)。结论 NI患者存前瞻性记忆与工作记忆损伤,前瞻性记忆损伤与工作记忆损伤有一定相关性。

Objective To explore the correlation between prospective memory and working memory in first-episode treatment-naive patients with nonorganic insomnia（NI）. Methods From Jan 2015 to Jan 2015, a total of 80 first-episode treatment-naive NI patients（NI group） in Anhui Provincial Mental Health Center were compared with gender-, age- matched 80 community volunteers as healthy controls（HC）. Prospective memory of them was assessed by Event-based prospective memory （EBPM） task and time-based prospective memory （TBPM） task. Working memory of them was assessed by object, verbal and spatial tasks. Pearson correlation analysis was used to analyze the correlation between prospective memory and working memory in NI group. Results The score of EBPM and TBPM in NI group was lower than that in HC group [（3.53±0.75）score vs （3.95±0.90）score; （3.15±1.16） score vs （3.75±1.07）score, all P 〈 0.05 ]. Reaction time of object and spatial working memory in NI group were longer than those in HC group [（1 448.95±294.54）ms vs （ 1 310.20 ±180.30）ms; （1 485.26±271.59）ms vs （1 397.68±268.08） ms, all P 〈0.05 ]. Pearson correlation analysis showed that EMPI score in NI group was negatively correlated with response time of object working memory （ r =-0.310, P = 0.005 ）. Conclusion NI patients exhibit prospective memory and working memory impairment. Prospective memory impairment is associated with working memory impairment.