卡贝缩宫素预防妊娠期高血压剖宫产产后出血的疗效及安全性评价

Efficacy and safety of cabernet in preventing postpartum hemorrhage after cesarean section in hypertensive disorder complicating pregnancy

目的:探讨卡贝缩宫素预防妊娠期高血压剖宫产产后出血的疗效及安全性分析。方法:100例妊娠期高血压剖宫产产妇作为研究对象,依据随机数字表法分为对照组(n=50)和观察组(n=50),对照组患者给予缩宫素治疗,观察组患者给予卡贝缩宫素联合缩宫素治疗,比较两组患者产后2 h、24 h出血量,产后出血例数、新生儿体重、新生儿窒息情况、产后24 h Hb下降值、第三产程、羊水性状以及药物不良反应率。结果:观察组产后2 h、24 h出血量以及产后出血例数均显著低于对照组(P<0.05);观察组产后24h Hb下降值显著低于对照组,第三产程时间显著短于对照组(P<0.05);两组新生儿1分钟Apgar评及羊水性状比较差异无统计学意义(P>0.05);观察组药物不良反应率显著低于对照组,差异有统计学意义(P<0.05)。结论:卡贝缩宫素可有效减轻妊娠期高血压剖宫产产后出血,安全性较高,具有一定临床价值。

OBJECTIVE To investigate the efficacy and safety of cabernet in preventing postpartum hemorrhage in patients with hypertensive disorder complicating pregnancy.METHODS A total of 100 cases of gestational hypertension cesarean section were selected as the research subjects,according to the random digital table method,were divided into control group（n=50）and observation group（n=50）.Patients in the control group were given oxytocin treatment,patients in observation group were treated with carbetocin combined with oxytocin.Blood loss of 2 h and 24 h postpartum hemorrhage,the case number of postpartum hemorrhage,the weight of the newborn,the neonatal asphyxia and the adverse drug reaction rate,postpartum24 hHb decline,third stage of labor and amniotic fluid characteristics were compared.RESULTS The blood loss of 2 h,24 h postpartum hemorrhage,the number of postpartum hemorrhage of the observation group were significantly lower than those in the control group（P〈0.05）.The decrease of 24 h Hb in the observation group was significantly lower than that in the control group,and the duration of labor in the third group was significantly shorter than that in the control group（P〈0.05）,and there were no significant difference in 1 min Apgar score and amniotic fluid（P〉0.05）.The adverse drug reaction rate in observation group was significantly lower than that in the control group（P〈0.05）.CONCLUSION Carbetocin induced hypertension during pregnancy can effectively reduce postpartum hemorrhage of cesarean section,has high safety,and certain clinical value.