纳米金抗菌机制及应用研究进展

Antibacterial mechanism and application of gold nanoparticles

细菌多重耐药是当今临床面临的一大挑战。纳米金(gold nanoparticles,AuNPs)因其独特的理化性质,无论是用作抗菌药物载体还是自身修饰后用作治疗剂,均在体内、体外展现出良好的抗菌效果。AuNPs的抗菌谱广,抗菌机制多样,且生物相容性好,具有良好的临床应用前景。但是对于其在体内环境下的结构稳定性、抗菌机制、长期安全性、表面修饰物的细胞毒性等的认知仍有待于通过后续研究深入探讨和完善。

Multi-drug resistance is a major clinical challenge today. The good antibacterial effect of gold nanoparticles （AuNPs） based on their unique physical and chemical properties make such systems ideal for application as antibacterial drug carriers or self-modifed therapeutic agents both in vitro and in vivo. AuNPs also have good clinical application prospects for their broad antibacterial spectrum, various antibacterial mechanisms and good biocompatibility. However, their structural stability in vivo, antibacterial mechanism, long-term safety and cytotoxicity of the surface modifcation have yet to be further explored and improved through subsequent studies.