运动性心肌肥大及其信号通路研究进展

Research Progress in Exercise Induced Myocardial Hypertrophy and Signaling Pathway

传统理论认为,运动性心肌肥大体现了机体对系统训练的生理适应,但最新的研究结果表明,运动诱导的心肌肥大会导致机体出现一些病理性的改变.相关研究证实,无论生理性心肌肥大或病理性心肌肥大,均具有鲜明的结构和分子基础,最具特征的信号通路则是PI3K和Gq信号通路.在介绍运动性心肌肥大机制的基础上,对心肌肥大的分类以及信号通路进行综述,以期更好地了解运动性心肌肥大,从而将运动性心肌肥大风险控制在最小范围.

Traditional theory holds that exercise-induced myocardial bypertrophy embodies the physiological adaptation of the body to the system training,but the recent research on the exercise-induced myocardial hypertrophy properties has generated controversy,saying that some pathological changes occur.The related research shows that the physiological myocardial hypertrophy and pathological myocardial hypertrophy have a distinct structure and molecular basis.The most typical signaling pathway is PI3K and Gq signaling pathways.In this paper,on the basis of the introduction of exercise-induced myocardial hypertrophy,the paper summarizes the classification of myocardial hypertrophy and its signaling pathways for better understanding of the exercise-induced myocardial hypertrophy,the minimization in risk control of exercise-induced myocardial hypertrophy.