2型糖尿病患者3-DG水平与中医证型相关性的临床研究

Clinical Study on the Relationship between the Level of 3-DG of T2DM Patients and TCM Patterns

目的:观察2型糖尿病患者3-脱氧葡萄糖醛酮(3-DG)水平与中医证型的相关性。方法:选取2015—2016年由苏州中医医院内分泌科确诊的98例2型糖尿病住院患者,按照证型分成3组:气滞痰热证组、气阴两虚证组、气阴两虚夹瘀证组,分析各组证型与3-DG数值的关系。结果:2型糖尿病中医证型与3-DG水平相关。糖尿病患者普遍3-DG水平较高,其中3DG异常升高与气阴两虚证密切相关(P<0.05)。且夹瘀者3-DG水平增高更明显。结论:3-DG水平增高与气阴二虚证密切相关,亦可能是导致糖尿病患者气阴两虚的原因;3-DG加重糖尿病患者机体瘀的程度,也加重了虚、损的程度,是并发症的不利因素。

Objective: To survey the relationship between the level of 3-deoxyglucosone(3-DG) of the patients suffering type 2 diabetes mellitus(T2DM) and TCM patterns. Methods: All 98 inpatients who were diagnosed as T2DM in endocrinology department of Suzhou Hospital of Traditional Chinese Medicine were chosen from 2015 to2016, and they were divided into three groups: the group of Qi stagnation and phlegm-heat pattern, Qi-Yin dual deficiency pattern and pattern of Qi-Yin dual deficiency mingled with stasis, to analyze the relationship between the patterns and the value of 3-DG. Results: The patterns of T2DM were related to the level of 3-DG. The level of 3-DG of the patients were commonly higher, among them, abnormal rise of 3-DG was closely related to Qi-Yin dual deficiency pattern(P <0.05), and the rise in 3-DG level in the patients mingled with stasis was more obvious.Conclusion: The rise in 3-DG level is closely connected to Qi-Yin dual deficiency pattern, which might be the cause of Qi-Yin dual deficiency of the patients; 3-DG aggravates the degrees of stasis of the patients′ bodies, and also the degrees of deficiency and waste, it is the adverse factor of the complications.