非高血压人群中血清尿酸和血压相关性研究

Study on correlation between serum uric acid and blood pressure in adults without hypertension

目的探讨非高血压人群中血清尿酸与血压(收缩压、舒张压和脉压)的关系。方法资料来自2017年6-12月在首都医科大学附属北京世纪坛医院体检中心体检健康人员的体检数据,总入选研究对象7 921例。依据血压分类标准分为收缩压正常值组(收缩压<120mm Hg)和收缩压正常高值组(120≤收缩压<140mm Hg);舒张压正常值组(舒张压<80mm Hg)和舒张压正常高值组(80≤舒张压<90mm Hg)。依据脉压水平分为脉压未升高组(脉压≤40mm Hg)和脉压升高组(脉压>40mm Hg)。酶法检测血清尿酸等指标水平,比较各组间各项指标的差异;采用多因素Logistic回归分析各参数与血压的关系。结果收缩压、舒张压正常值组与正常高值组、脉压未升高组与脉压升高组的血清尿酸水平比较,差异均有统计学意义(P<0.05);多因素Logistic回归分析显示,血清尿酸水平升高是收缩压(OR=1.237,95%CI:1.088～1.408,P=0.001)和舒张压(OR=1.315,95%CI:1.133～1.527,P<0.001)升高,而不是脉压(OR=0.853,95%CI:0.732～0.994,P=0.041)升高的独立危险因素。结论非高血压人群中血清尿酸水平升高是收缩压、舒张压升高而不是脉压升高的独立危险因素。进行血清尿酸水平检测可能有助于筛查出高血压高危人群。

Objective To investigate the correlation between serum uric acid and blood pressure（including systolic pressure,diastolic pressure and pulse pressure）in adults without hypertension.Methods Methods The research data were from physical examination center in Beijing Shijitan Hospital Affiliated to Capital Medical University during June to December,2017.The total number of research participants was 7 921.According to blood pressure levels,they were divided into the following groups：normal systolic blood pressure group（systolic blood pressure120 mmHg）and high-normal systolic blood pressure（120 ≤systolic blood pressure140 mmHg）;normal diastolic blood pressure group（diastolic blood pressure80 mmHg）and high-normal diastolic blood pressure group（80≤diastolic blood pressure90 mmHg）,normal pulse pressure group（pulse pressure≤40 mmHg）and high pulse pressure group（pulse pressure40 mmHg）.The levels of serum uric acid and other items were tested by enzyme method.The differences of clinical characteristics between the groups were compared.Multivariable logistic regression analysis were usede to analyze the relationship between clinical characteristics and test parameters and blood pressure.Results There were significant differences in serum uric acid levels between normal systolic and diastolic blood pressure group and normal high value group,non-elevated pulse pressure group and elevated pulse pressure group.Multivariate logistic regression analysis showed that serum uric acid level was an independent risk factor for the increase of systolic blood pressure（OR=1.237,95%CI：1.088-1.408,P=0.001）and diastolic blood pressure（OR=1.315,95%CI：1.133-1.527,P0.001）,but not for the increase of pulse pressure（OR=0.853,95%CI：0.732-0.994,P=0.041）.Conclusion Serum uric acid level in people without hypertension is an independent risk factor for the increase of diastolic blood pressure and systolic blood pressure,but not for increase of pulse pressure.Serum uric acid test may help to screen the high-risk population of hypertension.