LASS2表达对鼻咽癌患者术后复发监测意义研究

Effect of LASS2 expression on postoperative recurrence of nasopharyngeal carcinoma

目的探讨人源性长寿保障基因2(LASS2)对鼻咽癌患者术后复发的影响。方法收集2012年1月1日至2013年12月31日该院收治的154例鼻咽癌患者的活检标本和154例慢性鼻咽炎患者的活检标本。采用免疫组织化学法检测LASS2蛋白在鼻咽活检组织中的表达。并收集154例鼻咽癌标本患者的人口学资料和临床信息和复发情况,分析LASS2表达对鼻咽癌患者术后复发的影响。结果鼻咽癌组患者LASS2蛋白表达阳性率显著低于慢性鼻咽炎组,差异有统计学意义(χ~2=39.487,P=0.001)。复发鼻咽癌患者的临床分期、病理分期、LASS2表达、治疗方式和术后残留与不复发鼻咽癌患者比较,差异均有统计学意义(P<0.05)。LASS2阴性是鼻咽癌术后复发的独立危险因素(χ~2=36.472,优势比=0.233,95%可信区间:0.166～0.363,P=0.001)。结论 LASS2阴性鼻咽癌患者术后复发率明显高于LASS2阳性者,LASS2表达可成为鼻咽癌术后复发预测的生物学指标。

Objective To investigate the effect of homo sapiens longevity assurance homologue2 （LASS2） on the recurrence of nasopharyngeal carcinoma （NPC） after operation. Methods Biopsy specimens of 154 pa tients with nasopharyngeal carcinoma and 154 patients with chronic nasopharyngitis were collected from Janu ary 1,2012 to December 31,2013. The expression of LASS2 protein in nasopharyngeal biopsy tissues was de tected by immunohistochemistry. The demographic data, clinical information and recurrence of 154 nasopha ryngeal carcinoma patients were collected, and the effect of LASS2 expression on recurrence of nasopharyngeal carcinoma patients after operation was analyzed. Results The positive rate of LASS2 protein expression in na sopharyngeal carcinoma group was significantly lower than that in chronic nasopharyngitis group, and the difference was statistically significantχ2= 39. 487,P=0. 001）.There were significant differences in clinical stage, pathological stage, LASS2 expression, treatment methods and residual NPC patients compared with non recurrent NPC patients （P〈0.05）. Negative LASS2 was an independent risk factor for recurrence of nasopha ryngeal carcinoma （χ2= 36.472,OR=0.233,95%CI：0.166 0. 363 , P = 0. 001） . Conclusion The recurrence rate of patients with LASS2 negative nasopharyngeal carcinoma was significantly higher than that of patients with LASS2 positive. The expression of LASS2 can be a biological index for predicting the recurrence of naso pharyngeal carcinoma after operation.