穴位刺激配合系统化护理治疗氯氮平导致便秘的临床观察

Clinical Observation of Acupoint Stimulation and Systemic Nursing in Treating Constipation Caused by Clozapine

目的:观察穴位刺激配合系统化护理治疗氯氮平导致便秘的临床疗效。方法:将72例氯氮平所导致的精神分裂症便秘患者随机分为治疗组和对照组各36例。治疗组采用穴位刺激配合系统化护理,对照组给予系统化护理。治疗前后,采用便秘生存质量量表(PAC-QOL)评价2组患者的生存质量。结果:治疗结束后治疗组的疗效优于对照组(P <0. 05),治疗组总有效率91. 67%高于对照组总有效率72. 22%(P <0. 05); 2组患者PAC-QOL评分较治疗前均有下降,但治疗组评分降幅高于对照组(P <0. 05)。结论:穴位刺激配合系统化护理能够减轻氯氮平所导致的精神分裂症患者的便秘,改善其生存质量,且无副作用,值得临床推广运用。

[Objective] To observe the clinical effect of acupoint stimulation combined with systematic nursing on clozapine-induced constipation. [Method] 76 patients with constipation caused by clozapine were randomly divided into treatmentgroup and control group. The treatment group was used acupoint stimulation withsystematic nursing, while the control group only received systematic nursing. After treatment, the Constipation Patients Quality of Life Scale （PAC-QOL） was used to evaluate the quality of life. [Result] After treatment, the curative effect of the treatment group was better than that of the control group （P 〈0.05）, andthe total effective rate was 91.67% in the treatment group and 72.22% in the control group （ P 〈0.05）. The score of PAC-QOL in both groups was decreased comparedwith those before treatment, and the score of the treatment group was significantly lower than control group （ P 〈0.05）. [Conclusion] Acupuncture stimulation combined with systematic nursing can relieve constipation caused by clozapine in schizophrenia patients, improve their quality of life, and has no side effects. Itis worthy of clinical application.