益气除痰养阴方治疗Ⅳ期肺鳞癌的客观有效率及其对化疗毒副作用和肿瘤无进展生存期的影响研究

Effects of Yiqichutanyangyin Decoction on Objective Response Rate and Chemotherapy Side Effects and Progressionfree Survival among Patients with Stage Ⅳ Squamous Cell Lung Cancer

目的探讨益气除痰养阴方治疗Ⅳ期肺鳞癌的客观有效率及其对化疗毒副作用、肿瘤无进展生存期(PFS)的影响。方法选择2013年8月—2016年9月在广西中医药大学第一附属医院肿瘤科住院的Ⅳ期肺鳞癌患者79例,采用随机数字表法分为治疗组40例、对照组39例。治疗组接受化疗(GP方案)联合益气除痰养阴方治疗,对照组行GP方案化疗。两组患者均化疗4～6个周期,比较两组患者的客观有效率、化疗毒副作用、肿瘤PFS。结果两组患者客观有效率比较,差异无统计学意义(P>0.05);治疗组恶心、呕吐及粒细胞降低程度轻于对照组(P<0.05)。两组肿瘤PFS生存曲线比较,差异有统计学意义(P<0.05)。结论益气除痰养阴方不能提高Ⅳ期肺鳞癌患者的客观有效率,但能减轻化疗毒副作用,延长患者肿瘤PFS。

ObjectiveTo investigate the effects of Yiqichutanyangyin Decoction on objective response rate（ORR） and chemotherapy side effects and progression-free survival（PFS） among patients with stage Ⅳ squamous cell lung cancer.MethodsWe enrolled 79 inpatients with stage Ⅳ squamous cell lung cancer from Department of Oncology,the First Affiliated Hospital of Guangxi University of Chinese Medicine between August 2013 and September 2016 and randomized them into the treatment group（n=40） and the control group （n=39）,receiving chemotherapy with Gemcitabine and Cisplatin（GP） combined with Yiqichutanyangyin Decoction,chemotherapy with GP,respectively.Both groups were treated for 4-6 cycles.The ORR and chemotherapy side effects and PFS were compared between the groups at the end of treatment.ResultsBoth groups showed similar ORR（P〉0.05）.The treatment group demonstrated lower degree of chemotherapy-reduced nausea and vomiting and less reduction in granulocytes as well as a longer PFS compared with the control group（P〈0.05）.ConclusionFor patients with stage Ⅳ squamous cell lung cancer treated by chemotherapy with GP,although Yiqichutanyangyin Decoction could not improve the ORR,but the chemotherapy side effects could be reduced and the PFS could be prolonged.