磁共振灌注成像在乳腺癌新辅助化疗疗效评估中的应用分析

Analysis of Application of MR Perfusion Imaging in the Evaluation of Curative Effect of Neoadjuvant Chemotherapy

目的分析磁共振灌注成像在乳腺癌新辅助化疗疗效评估中的应用。方法方便选取该院2017年1—12月收治的100例乳腺癌患者为研究对象,依据疗效分组效应组(73例)和无效应组(23例),比较两组的一般资料及最大信号强度丢失率(MSILR)、肿瘤体积,并分析MSILR与肿瘤退缩率之间的相关性。结果两组一般资料比较,差异无统计学意义(P>0.05);效应组的肿瘤体积为(15.66±1.24)cm^3、MSILR为(12.33±8.54)%,与化疗前比较,差异有统计学意义(P<0.05),且与无效应组化疗后比较,差异有统计学意义(t=32.753、16.981,P<0.01);MSILR与肿瘤退缩率呈正相关(r=0.324,P=0.535)。结论乳腺癌新辅助化疗运用磁共振灌注成像评价疗效的临床价值肯定,其可预测乳腺癌新辅助化疗临床效果肯定。

Objective To analyze the application of MR perfusion imaging in the evaluation of curative effect of neoadjuvant chemotherapy. Methods 100 cases of patients with breast cancer admitted and treated in our hospital from January to December 2017 were convenient selected and divided into two groups according to the curative effect, including 73 cases in the efficacy group and 23 cases in the non-efficacy group, and the general data and MSILR, tumor size, were compared between the two groups, and the correlation between the MSILR and tumor regression rate was analyzed. Results The differences in the general data between the two groups were not statistically significant（P〉0.0）5, and the tumor size and MSILR in the efficacy group were respectively（15.66±1.24）cm3 and（12.33±8.54） %, and the difference was statistically significant before chemotherapy P〈0.05, and the difference between the two groups after chemotherapy was statistically significant（t=32.753, 16.981,P〈0.01）; and the MSILR was positively correlated with the tumor regression rate（r=0.324,P=0.535）. Conclusion The clinical value of breast cancer neoadjuvant chemotherapy in evaluating the curative effect is definite, and the clinical effect is worth recognition.