中医药干预特发性肺纤维化血管新生相关通路研究进展

Research Progress of Traditional Chinese Medicine on Angiogenesis Related Signaling Pathway in Treating Idiopathic Pulmonary Fibrosis

特发性肺纤维化是一种原因不明、不断进展、不可逆的,具有高致死性、纤维化性、间质性的肺疾病。目前西医尚无有效的治疗措施,而近年来研究表明血管新生与该疾病的发生、发展有密切联系。血管新生通路主要包括VEGF通路、PDGF通路、TGF-β信号通路,研究表明中医药能有效干预特发性肺纤维化血管新生相关通路,延缓特发性肺纤维化的进展。该文就中医药干预特发性肺纤维化血管新生相关通路的研究进展作一综述。

Idiopathic pulmonary fibrosis（IPF）is a cause of unknown,progressive,lethal,irreversible fibrosis interstitial lung disease. However,there is no effective treatment of Western medicine,and recent studies have shown that angiogenesis and the occurrence and development of the disease are closely linked. Angiogenesis pathway mainly includes VEGF pathway,PDGF pathway,TGF-β signaling pathway,studies have shown that Chinese medicine can effectively intervene in idiopathic pulmonary fibrosis angiogenesis related pathway,delay the progress of idiopathic pulmonary fibrosis. This article reviews the progress of traditional Chinese medicine intervention in angiogenesis related pathways in idiopathic pulmonary fibrosis.