PLR、NLR水平与急性脑梗死患者颈动脉粥样硬化斑块稳定性的关系

Relationship between PLR, NLR levels and stability of carotid atherosclerotic plaque in patients with acute cerebral infarction

目的探讨血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)水平与急性脑梗死(ACI)患者颈动脉粥样硬化斑块的关系。方法纳入86例ACI患者及30例健康体检者,收集临床资料,应用彩色多普勒超声仪检测颈动脉内膜中层厚度(IMT)。分析PLR、NLR水平与颈动脉粥样硬化斑块的关系。结果不稳定斑块组及稳定斑块组PLR、NLR水平均明显高于对照组(P<0.05),不稳定斑块组PLR、NLR水平明显高于稳定斑块组(P<0.01);Spearman相关分析结果显示,PLR、NLR与hs-CRP呈正相关(r=0.839,P=0.000;r=0.810,P=0.000);Logistic回归分析显示,hs-CRP、PLR、NLR水平是影响斑块稳定性的独立危险因素;PLR的曲线下面积(AUC)为0.859(95%CI:0.778～0.939,P=0.000),NLR的AUC值为0.781(95%CI:0.678～0.884,P=0.000)。结论 ACI患者PLR、NLR水平明显增高,与颈动脉粥样硬化斑块稳定性密切相关。

Objective To investigate the relationship between platelet-lymphocyte ratio （PLR）,neutrophil-lymphocyte ratio （NLR） and carotid atherosclerotic plaque in patients with acute cerebral infarction （ACI）. MethodA total of 86 patients with ACI and 30 healthy subjects were enrolled. Clinical data were collected and carotid artery intima-media thickness （IMT） was measured by color Doppler sonography. The relationship between PLR, NLR levels and carotid atherosclerotic plaque was analyzed. Results The levels of NLR and PLR in unstable plaque group and stable plaque group were significantly higher than those in control group （P〈0.05）. The levels of NLR and PLR in the unstable plaque group were significantly higher than those in the stable plaque group （P〈0.01）. Spearman correlation analysis showed that there was a positive correlation between PLR, NLR and hs-CRP （r=0.839, P=0.000; r=0.810, P=0.000）. Logistic regression analysis showed that hs-CRP, NLR and PLR levels were independent risk factors for plaque stability. The area under curve （AUC） of PLR was 0.859 （95% CI： 0.778-0.939, P=0.000）. The AUC of NLR was 0.781 （95% CI： 0.678-0.884, P=0.000）. ConclusionThe levels of PLR and NLR in ACI patients are significantly increased, which were closely related to the stability of carotid atherosclerosis plaque.