宣清化痰汤治疗儿童咳嗽变异性哮喘的临床研究

Clinical Study on Xuanqing Huatan Decoction in Treatment of Cough Variant Asthma in Children

目的：研究宣清化痰汤治疗儿童咳嗽变异性哮喘（CVA）的临床疗效。方法：将2016年4月—2017年4月本院收治的68例CVA患儿随机分为给予宣清化痰汤＋常规西药治疗的联合组（34例）和给予常规西药治疗的对照组（34例）,比较两组治疗效果。结果：联合组总有效率为94. 12%,显著高于对照组的76. 47%（P 〈0. 05）;治疗前,两组咳嗽、咽痒、气急及咯痰症状评分比较,均无显著性差异（P〉 0. 05）;治疗后,两组咳嗽、咽痒、气急及咯痰症状评分均显著降低（P 〈0. 05）,且联合组各症状评分的降低幅度均大于对照组（P 〈0. 05）;治疗前,两组肺功能指标和嗜酸性粒细胞（EOS）百分比比较,无显著性差异（P〉 0. 05）;治疗后一秒用力呼气容积（FEV1）、FEV1/用力肺活量（FVC）、PEF占预计值百分比（PEF pred%）均显著高（P 〈0. 05）,EOS百分比均显著下降（P 〈0. 05）,联合组变化幅度均大于对照组（P 〈0. 05）;两组治疗前后各项生命体征均无明显异常,对照组有2例出现轻微头晕,大便稀糊2例;联合组2例大便次数增多;均给予相应治疗后恢复正常。两组均无严重不良反应。结论：宣清化痰汤可有效改善CVA儿童的临床症状和肺功能,降低EOS百分比,疗效显著,且安全性高。

Objective： To study the clinical efficacy of Xuanqing Huatan Decoction in the treatment of cough variant asthma（CVA） in children. Methods： Sixty-eight children with CVA treated in the hospital from April 2016 to April 2017 were randomly divided into the combined group（treated with Xuanqing Huatan Decoction and routine western medicine,n = 34） and the routine group（treated with routine western medicine,n = 34）,and the treatment effects were compared between the two groups. Results：The total effective rate of the combined group was significantly higher than that of the control group（94. 12% vs 76. 47%）（P〈0.05）. Before treatment,there was no significant difference between the two groups in scores of cough,throat itching,shortness of breath or expectoration（P〈0.05）. After treatment,the above-mentioned scores decreased significantly in the two groups（P〈0.05）,and the decrease in the combined group was greater than that in the control group（P〈0.05）. Before treatment,there was no significant difference between the two groups in lung function indexes or the percentage of eosinophil（EOS）（P〈0.05）. After treatment,the forced expiratory volume in one second（FEV1）,FEV1/forced vital capacity（FVC） and the percentage of PEF in predicted value（PEF pred%） were significantly increased while the percentage of EOS was decreased significantly（P〈0.05）,and changes of above-mentioned indexes in the combined group were greater than those in the control group（P〈0.05）. There were no obvious abnormalities of vital signs in the two groups before and after treatment. There were two patients with mild dizziness and two patients with loose stools in the control group,two patients with increased stool frequency in the combined group,and after corresponding treatment,they all recovered. There were no serious adverse reactions in the two groups. Conclusion： Xuanqing Huatan Decoction can effectively relieve the clinical symptoms and improve the pulmonary function in children with CVA,and reduce the percentage of EOS. The curative effect is remarkable,and the safety is high.