新疆维吾尔族和汉族女性乳腺癌患者钼靶X线表现与免疫组织化学指标表达差异

Differences of mammographic findings and immunohistochemical markers in Xinjiang Uygur and Han women with infiltrating ductal carcinoma of breast

目的比较新疆地区维吾尔族(维族)与汉族女性乳腺浸润性导管癌患者钼靶X线表现、免疫组织化学指标差异。方法 42例维族女性乳腺浸润性导管癌患者(维族组),122例汉族女性乳腺浸润性导管癌患者(汉族组),术前均行乳腺钼靶X线检查,并取手术切除组织标本检测雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)、人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)、细胞增殖核抗原Ki-67阳性表达。结果汉族组钼靶X线检出肿块68例,维族组检出28例;维族组肿块伴钙化比率(64.29%)明显高于汉族组(41.18%)(P<0.05);维族组HER-2、Ki-67阳性表达率(76.2%、95.2%)均高于汉族组(34.4%、72.1%)(P<0.05),ER、PR阳性表达率(76.2%、66.7%)与汉族组(62.3%、54.1%)比较差异无统计学意义(P>0.05);维族组钼靶X线表现为肿块伴钙化者HER-2、Ki-67阳性表达率(75.0%、76.9%)高于汉族组(25.0%、42.3%)(P<0.05),表现为单纯肿块者ER、PR阳性表达率(16.7%、15.0%)低于汉族组(73.9%、65.0%)(P<0.05);2组ER、PR、HER-2、Ki-67阳性表达率在肿块边缘有无毛刺、分叶上差异无统计学意义(P>0.05)。结论维、汉族女性乳腺浸润性导管癌患者HER-2、Ki-67表达存在差异,且维族钼靶X线表现肿块伴钙化者HER-2、Ki-67表达率高于汉族。

Objective To compare the differences of the mammographic features and immunohistochemical markers of infiltrating ductal carcinoma of breast（IDCB）between Uygur and Han women in Xinjiang.Methods Mammography was performed in 42 Uygur IDCB patients（Uygur group）and 122 Han IDCB patients（Han group）before operation,and the expressions of estrogen receptor（ER）,progesterone receptor（PR）,human epidermal growth factor receptor 2（HER-2）and Ki-67 were detected after operation.Results Mammography results showed masses in 68 patients in Han group and28 patients in Uygur group.The calcification rate of mass was significantly higher in Uygur group（64.29%）than that in Han group（41.18%）（P0.05）.The positive rates of HER-2 and Ki-67 were significantly higher in Uygur group（76.2%,95.2%）than those in Han group（34.4%,72.1%）（P0.05）,and there were no significant differences in the positive rates of ER and PR between Uygur group（76.2%,66.7%）and Han group（62.3%,54.1%）（P0.05）.The positive rates of HER-2 and Ki-67 in patients with calcified mass were significantly higher in Uygur group（75.0%,76.9%）than those in Han group（25.0%,42.3%）（P0.05）.The positive rates of ER and PR in patients with simple mass were significantly lover in Uygur group（16.7%,15.0%）than those in Han group（73.9%,65.0%）（P0.05）.There were no significant differences in the positive rates of ER,PR,HER-2 and Ki-67 between the patients with and without defined-shape edges and lobulated tumor in both two groups（P0.05）.Conclusion Both HER-2 and Ki-67 are expressed differently between Uygur and Han women with IDCB,and the positive rates of HER-2 and Ki-67 in patients with calcified mass are higher in Uygur patients than those in Han patients.