应用平行检测法研究前列腺癌患者血清D二聚体、C反应蛋白水平及临床价值

Study on the Level of Serum D-dimer and C-reactive Protein in Patients with Prostate Cancer by Parallel Detection and its Clinical Value

目的研究分析应用平行检测法研究前列腺癌患者血清D二聚体(D-D)、C反应蛋白(CRP)水平及临床价值。方法对我院在2015年3月至2016年10月期间收治的62例前列腺癌患者的临床资料纳入研究对象设为观察组,且根据前列腺癌患者体内前列腺特异性抗原(PSA)的指标分为观察组(1)、(2)、(3)(根据<15 ng,15～25 ng及>20 ng指标),同时选取本院确诊为良性前列腺增生(BPH) 62例患者临床资料纳入研究对象设为对照组,并对其进行回顾性分析;对两组患者均采用平行检测法,检测其血清内D-D、CRP水平及凝血指标、并予以分析。结果观察组患者凝血酶原时间及活化部分凝血活酶时间、凝血酶时间及纤维蛋白原等各项指标同对照组相比无明显差异(P>0.05),观察组患者的病症程度差异同对照组D-D、CRP存在明显差异(P<0.05),且当PSA指标越高时,其D-D、CRP也明显升高(P<0.05)。结论前列腺癌患者血清D-D及CRP水平可同PSA联检并评估其患者的诊断及病症程度,有利于了解前列腺癌患者的病情进展及预后。

Objective to investigate and analyze the level of serum d-dimer（D-D）,c-reactive protein（CRP） and clinical value in patients with prostate cancer by parallel detection.Methods In our hospital from March 2015 to October 2015 admitted during the period of the clinical data of 62 patients with PCa into the research object as observation group,and based on prostate cancer patients prostate specific antigen（PSA）indicators divided into observation group（1）,（2）,（3）（according to the 15 ng,15 to 25 ng and 20 ng index）,at the same time selection in our hospital diagnosed as benign prostatic hyperplasia（BPH） in 62 patients clinical data into the research object is set to the control group,and were retrospectively analyzed.On two groups of patients adopt parallel test,detecting the serum D-D,CRP level indicators and make a detailed statistical analysis,blood coagulation indexes of the patients were observation.Results Observation group patients blood coagulation indexes as compared with the control group no significant difference（P〈0.05）,the differences in the observation group of patients condition and with the control group D-D,CRP level exists significant differences（P〈0.05）,and when PSA index is higher,the D-D and CRP level increased significantly（P〈0.05）.Conclusion prostate cancer patients serum D-D and CRP level is with PSA joint inspection and assessment,the degree of the patient＇s diagnosis and symptoms is helpful to understand the progression and prognosis of prostate cancer patients