升阳除湿汤联合匹维溴铵治疗肠易激综合征(脾虚湿阻)随机平行对照研究

Treatment of Irritable Bowel Syndrome(Spleen Deficiency and Dampness Blockage/脾虚湿阻) by Shengyang Chushei Decoction(升阳除湿汤) for Removing Dampness combined with Pion Bromide Randomized Parallel Controlled Study

[目的]观察升阳除湿汤联合匹维溴铵治疗肠易激综合征(脾虚湿阻)疗效。[方法]使用随机平行对照方法,将40例门诊患者按就诊顺序号方法随机分为两组。对照组20例匹维溴铵,50mg/次,3次/d。治疗组20例升阳除湿汤(苍术、羌活、防风各15g,柴胡、猪苓、升麻、泽泻各5g;神曲20g,陈皮15g,麦芽20g,甘草~炙6g;胃寒肠鸣,加半夏10g,益智仁15g,大枣20g,姜~生10g),水煎400mL,2次/d;匹维溴铵治疗同对照组。连续治疗5d为1疗程。观测临床表现、复发率、不良反应。治疗1疗程(4周),判定疗效。随访6个月,观测复发率。[结果]治疗组临床痊愈14例,显效5例,无效1例,总有效率95.00%;对照组临床痊愈10例,显效4例,无效6例,总有效率75.00%;治疗组疗效优于对照组(P<0.05)。随访6个月,复发率两组无显著差异(P>0.05)。[结论]升阳除湿汤联合匹维溴铵治疗肠易激综合征(脾虚湿阻),疗效满意,无严重不良反应,值得推广。

[Objective] To observe the curative effect of Shengyang Chushei decoction combined with pivoxilbromide on irritable bowel syndrome（Spleen Deficiency and Dampness Obstruction）. [Methods] Forty outpatients were randomly divided into two groups according to the order of visiting. In the control group, 20 cases were treated with 50 mg, 3 times/d. The treatment group of 20 cases of Shengyang Chushei decoction（Cangzhu, Qianghuo, Fangfeng each 15 g, Chaihu, Zhuling,Shengma, Zexie each 5 g, Shenqu 20 g, Chenpi15 g, Maiya 20 g, Zhigancao 6 g; Weihan Changming add Banxia 10 g, Yizhiren 15 g, Dazao 20 g, Shengjiang10 g）, water decoction 400 mL, twice a day; Pividimum bromide treatment with the same control group.Continuous treatment of 5 d for 1 courses. Observe clinical symptoms and adverse reactions. The course of treatment was 1 weeks（4 weeks）, and the curative effect was judged. The recurrence rate was observed after6 months follow-up. [Results] In the treatment group, 14 cases were cured, 5 cases were markedly effective,1 case was ineffective, the total effective rate was 95.00%; in the control group, 10 cases were cured, 4 cases were markedly effective, 6 cases were ineffective, the total effective rate was 75.00%; the curative effect of the treatment group was better than that of the control group（P〈0.05）. Follow up for 6 months showed no significant difference in recurrence rate between the two groups（P〉0.05）. [Conclusion] Shengyang Chushei decoction combined with pivoxil bromide in the treatment of irritable bowel syndrome（Spleen Deficiency and Dampness Obstruction） has a satisfactory effect, no serious adverse reactions, and is worthy of promotion.