昌吉地区缺血性卒中后抑郁与高同型半胱氨酸血症的相关性

Correlation between Post stroke depression and High homocysteine in Changji area

目的探讨新疆昌吉地区缺血性卒中后抑郁(PSD)与高同型半胱氨酸血症(HHcy)的相关性。方法收集昌吉市人民医院神经科2017年1月-2018年2月入住的缺血性卒中患者,分为缺血性卒中后抑郁组(PSD组)53例、缺血性卒中组(CIS组)85例,同期纳入健康人群为对照组(HC组)85例。三组均测定血清同型半胱氨酸(Hcy)水平并进行汉密尔顿抑郁量表(HAMD)评分,比较各组中Hcy水平及HAMD评分值,了解PSD与HHcy的相关性。结果 PSD组、CIS组、HC组中Hcy浓度均值分别为(19.36±11.30)umol/L、(13.74±6.44)umol/L、(11.98±5.03)umol/L。Hcy浓度PSD组同其它两组比较均有统计学差异,CIS组同HC组比较无统计学差异。HAMD评分值三组分别为(11.02±0.54),(5.00±0.93),(5.73±1.83)。HAMD评分值三组间比较均存在统计学差异。结论昌吉地区卒中后抑郁的发生同血浆同型半胱氨酸浓度增高存在相关性。

Objective To investigate the Correlation between Post stroke depression（PSD）and High homocysteine（HHcy）in Changji region of Xinjiang. Methods Ischemic stroke patients admitted by the department of neurology, Changji people＇s hospital from January 2017 to February 2018 were collected. There were 53 cases in the Post stroke depression group（PSD group）and 85 cases in the Cerebral infarction stroke group（CIS group）, while 85 cases in the Healthy controls group（HC group）were included in the healthy population at the same time. Serum homocysteine（Hcy）levels were measured in all three groups and the Hamilton depression scale（HAMD）score was conducted. Hcy levels and HAMD scores in each group were compared to understand the correlation between PSD and HHcy. Results The mean concentrations of Hcy in the PSD group, CIS group and HC group were respectively（19.36 ± 11.30）umol/L,（13.74 ± 6.44）umol/L,（11.98 ± 5.03）umol/L, respectively. There were statistically significant differences between the Hcy concentration PSD group and the other two groups, and there was no statistical difference between CIS group and HC group. The HAMD scores were respectively（11.02 ± 0.54）,（5.00 ± 0.93）,（5.73 ± 0.93）. There were statistically significant differences between the three groups of HAMD scores. Conclusion Post stroke depression and High homocysteine in Changji area exist correlation.