α-硫辛酸联合依帕司他治疗糖尿病痛性神经病变的临床效果观察

Observation on clinical effect of α-thioctic acid combined with epalrestat in the treatment of diabetic painful neuropathy

目的对糖尿病痛性神经病变患者采用α-硫辛酸联合依帕司他治疗的效果进行分析和讨论。方法 50例糖尿病痛性神经病变患者,按照治疗方法不同分为对照组和研究组,每组25例。对照组患者接受单纯的α-硫辛酸治疗方案,研究组患者接受α-硫辛酸联合依帕司他治疗方案。对两组治疗效果以及生活质量评分进行对比。结果对照组与研究组患者的治疗总有效率分别为76.00%和96.00%,研究组治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。研究组患者的总体健康、生理健康、精神健康、生理功能、情感职能、躯体疼痛以及社会功能评分均明显高于对照组,差异具有统计学意义(P<0.05)。结论在治疗糖尿病痛性神经病变过程中,应用α-硫辛酸联合依帕司他治疗方案,不仅可以改善患者疼痛程度,同时也能够促进生活质量的提高,在临床中值得不断采纳和推广。

Objective To analyze and discuss the effect of α-thioctic acid combined with epalrestat in the treatment of patients with diabetic painful neuropathy. Methods A total of 50 patients with diabetic painful neuropathy were divided by different treatment methods into control group and research group, with 25 cases in each group. The control group received simple α-thioctic acid regimen, and the research group received α-lipoic acid combined with epalrestat regimen. The treatment effect and quality of life score in two groups was compared. Results The total treatment effective rate of control group and research group were 76.00% and 96.00% respectively. The total treatment effective rate of the research group was significantly higher than the control group, and the difference was statistically significant（P〈0.05）. The overall health, physical health, mental health, physical function, emotional function, physical pain, and social function score in research group were obviously higher than the control group, and their difference was statistically significant（P〈0.05）. Conclusion In the treatment of diabetic painful neuropathy, the application of α-thioctic acid combined with epalrestat can not only improve the pain level of patients, but also promote the improvement of quality of life. So it is worthy of continuous adoption and promotion in clinical practice.