苍附排卵汤干预对行体外受精-胚胎移植治疗多囊卵巢综合征不孕患者胚胎质量的影响

Effect of Cangfu Pailuan decoction on embryo quality of patients with PCOS treated by IVF-ET

目的观察苍附排卵汤对行体外受精-胚胎移植(IVF-ET)治疗的肥胖型多囊卵巢综合征(PCOS)不孕患者的临床影响。方法将符合条件的58例痰瘀互结型患者按照平行对照观察法分为对照组(31例)和中药组(27例),比较各组超促排卵过程中各项指标,并随访患者中医证候、体质量、OHSS等并发症情况。结果中药组治疗后BMI、中医证候评分、月经颜色与治疗前比较差异均有统计学意义(P <0.05),而对照组中医证候评分与体质量治疗前后均无明显改变;2组MI卵率比较对照组57.88%,中药组80.95%(P <0.05);2组优胚率比较对照组61.48%,中药组77.13%(P <0.05);2组扳机日血清性激素水平、促性腺激素(Gn)用量、Gn天数及扳机日> 14 mm卵泡数及> 18 mm卵泡数比较差异无统计学意义(P> 0.05);2组获卵率、受精率、卵裂率比较差异无统计学意义(P> 0.05)。结论苍附排卵汤有助于降低多囊卵巢综合征患者BMI,改善肥胖型多囊卵巢综合征患者的临床症状;苍附排卵汤在IVF-ET促排卵周期中可有效提高MI卵率及优胚率。

Objective Observe the influence of Cangfu Pailuan decoction intervention on the weight and embryo quality of the obese polycystic ovary syndrome（PCOS） infertile patients under IVF-ET treatment. Methods Patients with phlegm and blood stasis were divided into control group（n = 31） and traditional Chinese medicine group（n = 27） as the parallel control method. Control group and traditional Chinese medicine were compared in regard to the parameters of controlled ovary stimulation. And follow-up of patients with TCM syndromes, weight, OHSS and other complications. Results After treatment, BMI, the score of TCM symptom and menstrual color were significantly higher than before in treatment group（P〈0.05）. However, there were no statistical differences in control group before and after treatment.The MII oocyte rate of control group is 57.88% and that of the test group is 80.95%（P〈0.05）. The high quality embryo rate of the control group is 61.48% and that of the test group is 77.13%（P〈0.05）. The serum hormone value of trigger day, the usage amount and days of Gn, both groups of14 mm follicular number and18 mm follicular number at the trigger day did not shou remarkable differences between two groups（P〈0.05）. There were also no significance in oocyte obtain rate, fertility rate and cleavage rate between the two groups（P〈0.05）. Conclusions The Cangfu Pailuan decoction contributes to reduce the BMI index of the PCOS patients, improve the clinical symptom of the obese PCOS patients. By using the Cangfu Pailuan decoction, the PCOS patient＇ MII oocytes rate and high quality embryo rate during the IVF-ET ovulation stimulation cycle can be improved effectively.