氟哌噻吨美利曲辛联合雷贝拉唑治疗非糜烂性胃食管反流病伴焦虑抑郁的效果观察

Effects of fluperthiol-melitracen combined with rabeprazole on NERD patients with anxiety and depression

目的 探究氟哌噻吨美利曲辛（FM）联合雷贝拉唑对非糜烂性胃食管反流病（NERD）伴有焦虑抑郁情绪患者的治疗效果.方法 选取濮阳市安阳地区医院2016年1月至2017年7月收治的87例NERD患者,随机分为两组.单药组43例患者予雷贝拉唑和心理指导,联合组44例患者在单药组治疗基础上加用FM.治疗后1个月比较两组疗效及患者焦虑与抑郁状态.结果 联合组治疗后1个月症状评分、汉密尔顿焦虑量表（HAMA）评分及汉密尔顿抑郁量表（HAMD）评分均低于单药组,总有效率高于单药组,差异有统计学意义（P〈0.05）.结论 FM联合雷贝拉唑可改善NERD伴焦虑抑郁患者的症状及焦虑抑郁情绪,疗效较好,值得推广.

Objective To investigate the therapeutic effects of flupentixol-melitracen （ FM） and rabeprazole on patients with non-erosive reflux disease （NERD） with anxiety and depression .Methods A total of 87 patients with NERD complicated by anxiety and depression , who were treated in Puyang Anyang Regional Hospital from January 2016 to July 2017 were randomly divided into two groups .Forty-three patients in monotherapy group were given reazolazole and psychological guidance .Forty-four patients in combined group were treated with FM on the basis of treatment for monotherapy group .The efficacy and condition of anxiety and depression of the two groups were compared 1 month after treatment . Results Symptom scores, Hamilton anxiety scale （ HAMA） and Hamilton depression scale （ HAMD） scores in combined group were lower than those in monotherapy group 1 month after treatment , but the total effective rate was higher than that in monotherapy group , and the difference was statistically significant （P〈0.05）.Conclusions FM combined with rabeprazole can improve the symptoms and emotion of NERD patients with anxiety and depression , with better therapeutic effect .It is worth promoting in clinic .