肿痛安胶囊联合醋酸地塞米松粘贴片治疗复发性口腔溃疡的临床研究

Clinical study on Zhongtongan Capsules combined with Dexamethasone Acetate Adhesive Tablets in treatment of recurrent oral ulceration

目的研究肿痛安胶囊联合醋酸地塞米松粘贴片治疗复发性口腔溃疡的临床疗效。方法选取2015年6月—2017年6月在天津医科大学第二医院接收的120例复发性口腔溃疡患者作为研究对象,将所有患者分为对照组和治疗组,每组各60例。对照组患者给予醋酸地塞米松粘贴片贴附在患处,早晚各1次;治疗组患者在对照组治疗的基础上口服肿痛安胶囊,2粒/次,3次/d。两组患者均连续治疗10 d。观察两组患者的临床疗效,比较两组治疗前后的炎症因子水平和溃疡复发率。结果治疗后,对照组和治疗组的总有效率分别为80.00%、95.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组白细胞介素2(IL-2)水平显著降低,白细胞介素4(IL-4)水平显著升高,两组比较差异具有统计学意义(P<0.05);且治疗后治疗组炎性因子水平显著优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗半年后,对照组和治疗组的溃疡复发率分别为21.67%、5.00%,两组比较差异具有统计学意义(P<0.05)。结论肿痛安胶囊联合醋酸地塞米松粘贴片治疗复发性口腔溃疡具有较好的临床疗效,能够降低炎性因子水平,降低复发率,具有较好的临床推广应用价值。

Objective To study the clinical effect of Zhongtongan Capsules combined with Dexamethasone Acetate Adhesive Tablets in treatment of recurrent oral ulceration. Methods Patients（120 cases） with recurrent oral ulceration in the Second Hospital of Tianjin Medical University from June 2015 to June 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were given Dexamethasone Acetate Adhesive Tablets, attached to the affected area, 1 time in the morning and evening. Patients in the treatment group were po administered with Zhongtongan Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the inflammatory factors levels and ulcer recurrence rates in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.00% and 95.00%, respectively, and there were differences between two groups（P〈0.05）. After treatment, IL-2 levels were significantly decreased in two groups, but IL-4 levels were significantly increased, and there were differences in the same group（P〈0.05）. After treatment, the inflammatory factors levels in the treatment group were better than those in the control group, and there were differences between two groups（P〈0.05）. After six months of treatment, the ulcer recurrence rate in the control and treatment groups was 21.67% and 5.00%, respectively, and there were differences between two groups（P〈0.05）. Conclusion Zhongtongan Capsules combined with Dexamethasone Acetate Adhesive Tablets has significant clinical effect in treatment of recurrent oral ulceration, can decrease the levels of inflammatory factors and the recurrence rate, which has a certain clinical application value.