过氧化氢气溶胶空气消毒对呼吸机相关肺炎的防控效果分析

Research on the efficacy of hydrogen peroxide aerosol air disinfection in the prevention of ventilator-associated pneumonia

目的评价过氧化氢气溶胶空气消毒对重症监护病房(ICU)内住院患者呼吸机相关肺炎(VAP)的预控效果。方法通过医院感染监测方法,分析过氧化氢气溶胶空气消毒前后7 d内ICU的VAP感染率变化情况。结果调查期间某医院ICU收治患者4 455例次,发生VAP 242例次,VAP例次感染率为5. 43%。Fisher统计分析显示,干预前后3～5 d内VAP发病率下降具有统计学意义,但干预前后1～2 d和6～7 d VAP发病率下降无统计学意义。结论过氧化氢空气消毒可降低ICU内VAP的医院感染率,但防控效果具有一定的滞后性和衰减性。

Objective To evaluate the preventive efficacy of hydrogen peroxide aerosol air disinfection for ventilator-associated pneumonia（ VAP） in an Intensive Care Unit（ ICU） in a hospital. Methods By monitoring nosocomial infection in an ICU ward,the VAP infection rates within 1-7 days before and after the hydrogen peroxide air disinfection were analyzed. Results There were 242 VAP episodes diagnosed among 4 455 inpatients,and the VAP incidence was 5. 43% during the whole observational period. Fisher test manifested that VAP infection rates within 3-5 days before and after intervention were significant,but those VAP infection rates within 1-2/6-7 days before and after intervention were not significant. Conclusion Hydrogen peroxide aerosol air disinfection can reduce VAP incidence in ICU patients,and the preventive efficacy is characterized by the delay and attenuation.