临床分离金黄色葡萄球菌的耐药性及其对消毒剂抗性研究

Research on drug resistance and disinfectant resistance of Staphylococcus aureus from clinic

目的研究临床分离金黄色葡萄球菌的耐药性及其对消毒剂的抗性,为临床干预与研究提供依据。方法采用药敏试验和悬液定量杀菌试验方法,对某医院临床分离金黄色葡萄球菌耐药性和消毒剂抗性进行了观察。结果共分离出金黄色葡萄球菌1 021株,其中筛查出耐甲氧西林菌株(MRSA) 502株,占检出金黄色葡萄球菌总数的49. 17%。临床分离金黄色葡萄球菌对利奈唑胺、替加环素、万古霉素等抗菌药物全部敏感,对青霉素的耐药率为93. 93%。MRSA菌株对3种消毒剂的抗性略高于MSSA。结论临床分离金黄色葡萄球菌中MRSA菌株比例较高,对青霉素类几乎全部耐药,要求规范和科学使用抗菌药物。

Objective To investigate the drug resistance and disinfectant resistance of Staphylococcus aureus isolated from some hospital,so as to lay foundation for clinical intervention and study. Methods Drug sensitivity test and suspension quantitative germicidal test were used to observe the drug resistance and disinfectant resistance on Staphylococcus aureus isolated from some hospital. Results Totally 1 021 strains of Staphylococcus aureus were isolated,among which 502（ 49. 17%） strains were Methieillin-resistant Staphylococcus aureus（ MRSA）. The drug sensitive rates of Staphylococcus aureus to Inezolid,Tigocycline,and Vancomycin were all 100. 00%,and the resistant rate to Penicillin was 93. 93%. The resistance of MRSA to 3 kinds of disinfectants was slightly higher than that of MSSA. Conclusion Among Staphylococcus aureus strains isolated from clinic,the detection rate of MRSA is comparatively higher. Staphylococcus aureus is almost completely resistant to Penicillins. So we should select antibiotics normally for scientific using.