局部进展期胰腺癌的诊治策略进展

Progress in diagnosis and treatment of locally advanced pancreatic cancer

胰腺癌是常见的消化系统恶性肿瘤，发病隐匿，且发病率呈上升趋势。80％的患者确诊时已错失根治性手术切除机会。其中局部进展期胰腺癌患者（特指肿瘤局部广泛浸润，伴有严重血管侵犯而无远处转移的胰腺癌）约占全部胰腺癌患者的30％～50％，手术切除5年生存率5％～10％。目前胰腺癌发病机制尚不清楚，由于其缺乏特异性临床表现，早期诊断率低。为此，改善胰腺癌预后的重点在于提高局部进展期胰腺癌患者的临床疗效，本文就相关研究综述如下。

Pancreatic cancer, one of the common malignant tumors of the digestive system, is secretive in incidence and morbidity. Eighty percent of pancreatic cancer patients have already missed the opportunity of eradicative resection surgery when they were diagnosed, among whom, thirty to fifty percent of patients are in locally advanced tumor stage （ specifically signifying the local extensive infiltration of tumor with serious vascular invasion and without distant metastasis ） with a five-year survival rate of five to ten percent after excision. The pathogenesis of pancreatic cancer is still unclear, with a low rate of early diagnosis due to its lack of characteristic clinical manifestations. This paper reviewed the relevant studies on the clinical therapy of pancreatic cancer patients in locally advanced tumor stage, which is the key to improve the prognosis of pancreatic cancer.