摘要
线粒体ATP合酶是线粒体氧化磷酸化的关键酶,其功能缺陷会导致能量代谢障碍相关的线粒体疾病。线粒体ATP合酶是由多个亚基组成的蛋白复合物,其生物合成和组装是个复杂的生物过程。酵母是研究线粒体ATP合酶结构、生物合成和组装机制的模式实验材料之一,且相关研究取得了很多进展。本文概述了国内外用酿酒酵母研究线粒体ATP合酶的结构、调控线粒体ATP合酶亚基生物合成和组装的辅助蛋白及合酶的模块化组装过程的研究进展,以期为线粒体ATP合酶的工作机制及相关线粒体疾病的研究提供理论借鉴和参考依据。
Mitochondrial ATP synthase is one of key enzymes of mitochondrial oxidative phosphorylation. Functional deficiency in mitochondrial ATP synthase can lead to energy metabolism related mitochondrial disorders. Mitochondrial ATP synthase consists of multiple subunits, and its biogenesis and assembly is a complicated biological process. Yeast is one of model organisms fo r studying structure, biogenesis and assembly mechanism of mitochondrial ATP synthase, and many progress has been made in related research. This review summarizes the research progress in the structure, biogenesis and assembly regulator factors, and modular assembly process of Saccharomyces cerevisiae mitochondrial ATP synthase, providing references for study of working mechanism of mitochondrial ATP synthase and of related mitochondrial diseases.
作者
杨光影
赵彤
田静涵
翁俊
曾小美
YANG Guang-Ying;ZHAO Tong;TIAN Jing-Han;WENG Jun;ZENG Xiao-Mei(Key Laboratory of Molecular Biophysics of Ministry of Education,Center for Human Genome Research,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China)
出处
《菌物学报》
CAS
CSCD
北大核心
2018年第11期1424-1440,共17页
Mycosystema
基金
国家自然科学基金(31400665)
湖北省自然科学基金(2017CFB692)~~
关键词
线粒体ATP合酶
酿酒酵母
结构
生物合成
组装过程
mitochondrial ATP synthase
Saccharomyces cerevisiae
structure
biogenesis
assembly process
