喉镜下化疗及雾化吸入乙酰半胱氨酸溶液诊疗喉结核的疗效评价

Evaluation of the Therapeutic Effect of Laryngoscopic Chemotherapy and Aerosolizedinhalation of Acetylcysteine on the Diagnosis and Treatment of Laryngeal Tuberculosis

目的比较分析喉镜下化疗及雾化吸入乙酰半胱氨酸溶液诊疗喉结核的疗效评价。方法治疗组治疗总有效率较参照组高,差异有统计学意义;进行单一因素与多因素分析,表明声音嘶哑、咳嗽、充血水肿和呼吸困难是喉结核的重要影响因素。选取酒泉市第二人民医院收治的疑诊喉结核患者79例,按随机原则分成参照组(常规喉结核治疗)35例和治疗组(喉镜下化疗联合雾化吸入乙酰半胱氨酸溶液进行治疗)44例,两个月后观察治疗效果。结果治疗后,治疗组治疗总有效率(88.63%)较参照组(68.57%)高,治疗组的声音嘶哑、咽喉疼痛、消瘦、发热、咳嗽和充血水肿等病症改善时间均明显小于参照组,差异均有统计学意义(P=0.019)。结论在基层医院的诊疗疗效中,能够有效降低临床不良反应,有利于临床医生对诊疗喉结核的疗效评价。

OBJECTIVE To compare the efficacy of laryngoscopy chemotherapy and aerosolized acetylcysteine solution in the diagnosis andtreatment of laryngeal tuberculosis. METHODS 79 patients with suspected laryngeal tuberculosis were collected from target hospital. Accordingto the random principle,35 patients were treated with reference group（conventional laryngeal tuberculosis treatment）and treatedgroup（laryngoscopy chemotherapy combined with aerosolized acetylcysteine solution）. After 2 months,the treatment effect was observed.RESULTS After treatment,the total effective rate of the treatment group was（88.63%）higher than that of the control group（68.57%）.The clinical control of the treatment group was 27.46% better than that of the control group 20.43%. The treatment group had hoarseness,sore throat,wasting and fever. The improvement time of cough and hyperemia were significantly shorter than that of the control group（P=0.019）. CONCLUSION In the diagnosis and treatment of primary hospitals, it could effectively reduce the clinical adverse reactions,which is conducive to the clinician’s evaluation of the efficacy of diagnosis and treatment of laryngeal tuberculosis.