磁共振分子影像学研究进展

Research progress in molecular magnetic resonance imaging

磁共振分子影像是分子影像学的重要分支,具有其他成像技术不可比拟的优越性和广阔的发展前景。近年来,新型磁共振靶向探针及成像序列的研发取得了一系列进展,包括可激活探针、19F成像、超极化成像以及化学交换饱和转移成像等方面,进一步拓展了磁共振分子影像的应用范围。此外,磁共振分子成像在多系统疾病的早期诊断、代谢成像、细胞示踪及基因分析等方面也发挥着巨大优势。尽管磁共振分子成像距离临床转化还存在着一定差距,随着成像技术的日新月异,其在临床疾病诊治中必将发挥重要价值。

As a major method of molecular imaging, molecular magnetic resonance imaging(mMRI) has overwhelming advantages and broad application prospect. In recent years, major progresses were made in this field, especially on the development of novel molecular probes and imaging sequences. The successful application of activatable probes, fluorine 19 contrast agents, Chemical Exchange Saturation Transfer imaging and hyperpolarization techniques have broadened the application of mMRI. In addition, the mMRI has also been applied in the early diagnosis, metabolic imaging, cell tracking and gene analysis in various diseases. Although much strength is to be addressed before the clinical translation of the mMRI, the developing imaging techniques will guarantee the important role that mMRI will play in both the basic and clinical research.