钕与乌洛托品配合物的合成、表征及抗菌活性研究

Synthesis, Characterization and Antibacterial Activity of Complex for Neodymium with Urotropine

报道了配合物NdI3·C6 H1 2 N4 ·HI·13H2 O的新的合成方法 ,通过元素分析、X射线粉末衍射、红外光谱、核磁共振谱、质谱、差热 热重分析 ,确定了配合物的组成和结构 ,9个水分子与Nd3+ 形成配合阳离子 [Nd(H2 O) 9] 3+ ,C6 H1 2 N4 分子以N原子与Nd3+ 直接作用 ,而 3个I- ,HI以及剩余 4个水分子与配合阳离子 [Nd(H2 O) 9] 3+ 以静电引力或氢键的形式作用。首次测定了配体碘化钕、氢碘酸乌洛托品和配合物对枯草芽孢杆菌、大肠杆菌和葡萄球菌的抗菌活性。所有试样对枯草芽孢杆菌的杀死作用较对葡萄球菌、大肠杆菌的杀死作用显著 ,且高浓度溶液(0 .0 5mol·L - 1 )比低浓度溶液 (0 .0 1mol·L - 1 )的抗菌效果好。浓度为 0 .0 5mol·L - 1时 ,由于协同性 ,配合物NdI3·C6 H1 2 N4 ·HI·13H2

The complex NdI 3·C 6H 12 N 4·HI·13H 2O was synthesized with a new method. The complex was characterized by elemental analysis, methods of X ray powder diffraction, infrared analysis, nuclear magnetic resonance spectroscopy, mass spectroscopy, and thermogravimetry and differential thermal analysis. The coordinative cation [Nd(H 2O) 9] 3+ is formed by Nd 3+ and nine H 2O, C 6H 12 N 4 acts on Nd 3+ through N directly, three I -, HI and the rest H 2O act on [Nd(H 2O) 9] 3+ by the form of static attraction or hydrogen bond. And the antibacterial activity against escherichia coli, staphylococcus aureus and bacillus subtilis of neodymium iodide, urotropine hydriodide and the complex was studied. The results show that the antibacterial activity of all samples against bacillus subtilis is better than that against escherichia coli and staphylococcus aureus. The antibacterial activity of high concentration solution(0.05 mol·L -1 ) is better than that of low concentration(0.01 mol·L -1 ). The antibacterial activity of the complex NdI 3·C 6H 12 N 4·HI·13H 2O is better than that of corresponding coordinator.