2-(对氯苯基)肌氨酸的合成工艺研究

Study on the Synthetic Technology of 2-(p-Chlorophenyl) Sarcosine

以对氯苯甲醛为原料,经亲核加成和水解两步反应,合成了一种高效低毒农药的中间体2-(对氯苯基)肌氨酸。采用正交设计法考察了催化剂、反应温度、反应时间、水解时间等工艺条件对反应的影响,确定了最适宜的工艺条件:催化剂 TEBA,反应温度 85C,反应时间 16h,水解时间 5h,在此优化条件下,收率达91.5%。产物用IR谱图进行了表征。

The paper introduced a method using 4-chlorobentaldehyde as source material and via nucleophilic addition and hydrolyzation to synthesize the 2-(p-chlorophenyl) sarcosine, which is an intermediate of a high-efficient and low poisonous posticide. Based on orthogonal test, the influence factors of synthesis, such as catalyst, reaction temperature, reaction duration and hydrolyzation duration were investigated, and the optimum reaction conditions were found as following: catalyst TEBA, reaction temperature 85 C, reaction duration 16h, hydrolyzation duration 5h. Under these conditions, the yield could reach 91.5%. The structure of the product was identified by IR spectra.